From the FDA Drug Label
Rash and Possibly Allergic Events — In US fluoxetine clinical trials as of May 8,1995,7% of 10,782 patients developed various types of rashes and/or urticaria Among the cases of rash and/or urticaria reported in premarketing clinical trials, almost a third were withdrawn from treatment because of the rash and/or systemic signs or symptoms associated with the rash Anaphylactoid events, including bronchospasm, angioedema, laryngospasm, and urticaria alone and in combination, have been reported.
Yes, Prozac (fluoxetine) can cause allergic reactions, including:
- Rashes and/or urticaria
- Anaphylactoid events, such as bronchospasm, angioedema, laryngospasm, and urticaria These events can be serious and may require discontinuation of the medication 1.
From the Research
Yes, Prozac (fluoxetine) can cause allergic reactions in some people, though they are relatively uncommon. Signs of an allergic reaction may include skin rash, hives, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. Anyone experiencing these symptoms after taking Prozac should seek immediate medical attention as severe allergic reactions can be life-threatening. People with known allergies to fluoxetine or other selective serotonin reuptake inhibitors (SSRIs) should not take Prozac. Before starting Prozac, patients should inform their healthcare provider about all allergies and previous medication reactions. The mechanism behind these allergic reactions typically involves the immune system mistakenly identifying the medication as harmful and mounting a defensive response. This immune reaction can occur upon first exposure to the medication or after taking it for some time without previous problems. If an allergic reaction occurs, the healthcare provider may recommend discontinuing Prozac and switching to a different antidepressant, as suggested by a case report of cross-reacting allergy between serotonin uptake blockers 2. However, the most recent and highest quality study on SSRIs does not specifically address allergic reactions to fluoxetine 3, but an older study provides some insight into the side effects of fluoxetine, including minor symptoms of allergic reactions 4. Other studies have compared the safety and side-effect profiles of different SSRIs, including fluoxetine, but do not provide conclusive evidence on allergic reactions 5, 6. Given the potential for allergic reactions, it is essential to monitor patients taking Prozac for any signs of an allergic response and to discontinue the medication if necessary. In terms of morbidity, mortality, and quality of life, the risk of allergic reactions should be carefully weighed against the potential benefits of Prozac in treating depression and other conditions. Some key points to consider include:
- Monitoring for signs of allergic reactions, such as skin rash or itching
- Discontinuing Prozac if an allergic reaction occurs
- Informing healthcare providers about all allergies and previous medication reactions
- Considering alternative treatments if Prozac is not tolerated due to allergic reactions.