From the Guidelines
Methylsulfonylmethane (MSM) may be considered for treating joint pain, particularly in osteoarthritis, but its effectiveness is not conclusively established. The most recent and highest quality study on this topic is not directly provided in the given evidence, but based on the available information, MSM is believed to work by providing sulfur that helps form connective tissue, reducing inflammation, and acting as an antioxidant in joints 1. Typical dosages range from 1,500 to 6,000 mg daily, usually divided into 2-3 doses with meals. For best results, MSM should be taken consistently for at least 12 weeks before evaluating its effectiveness.
Some key points to consider when using MSM for joint pain include:
- Starting with a lower dose and gradually increasing while monitoring for benefits and side effects
- Discussing with a healthcare provider before starting MSM, especially if taking medications or having existing health conditions
- Potential side effects are generally mild and may include digestive discomfort, headaches, or skin rashes
- MSM is often combined with glucosamine and chondroitin for potentially enhanced benefits
It's essential to weigh the potential benefits and risks of using MSM, considering the individual's specific health conditions and medications. As with any supplement, it's crucial to consult with a healthcare provider to determine the best course of treatment for joint pain.
From the FDA Drug Label
Temporarily relieves minor aches and pains of muscles and joints associated with: simple backache arthritis strains bruises sprains Methylsulfonylmethane (MSM) is effective for temporarily relieving minor aches and pains of muscles and joints, including those associated with arthritis and simple backache 2.
- Key benefits: temporary relief of minor joint pain
- Target conditions: simple backache, arthritis, strains, bruises, sprains
From the Research
Efficacy of Methylsulfonylmethane for Joint Pain
- Methylsulfonylmethane (MSM) has been studied as a potential treatment for joint pain, particularly in the context of osteoarthritis (OA) 3, 4, 5, 6.
- A pilot clinical trial published in 2006 found that MSM produced significant decreases in pain and physical function impairment in patients with knee OA, compared to a placebo 3.
- A randomized controlled trial published in 2016 found that a combination of MSM and boswellic acids was effective in reducing pain and improving joint function in patients with knee arthritis, compared to glucosamine sulfate 4.
- However, a randomized controlled trial published in 2017 found that MSM did not provide significant improvements in knee pain or function in military initial entry trainees 5.
- Another study published in 2017 found that a combination of glucosamine, chondroitin sulfate, and MSM was more effective in reducing pain and improving joint function in patients with knee OA, compared to glucosamine and chondroitin sulfate alone or a placebo 6.
Mechanisms of Action
- The exact mechanisms of action of MSM in reducing joint pain are not fully understood, but it is thought to have anti-inflammatory and antioxidative properties 3, 4.
- MSM may also have a role in reducing the production of pro-inflammatory cytokines and increasing the production of anti-inflammatory cytokines 4.
- However, more research is needed to fully understand the mechanisms of action of MSM and its potential benefits in reducing joint pain.
Comparison to Other Treatments
- MSM has been compared to other treatments for joint pain, including glucosamine sulfate and boswellic acids 4, 6.
- A study published in 2021 reviewed the mechanisms of action of various treatments for OA pain, including acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies, but did not specifically discuss MSM 7.
- Further research is needed to compare the efficacy and safety of MSM to other treatments for joint pain.