What is the generic name of Actos (pioglitazone)?

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Generic Name of Actos

The generic name for Actos is pioglitazone hydrochloride 1.

Drug Classification and Chemical Identity

Pioglitazone belongs to the thiazolidinedione (TZD) class of oral antidiabetic agents 2. The complete chemical name is pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione monohydrochloride, with a molecular formula of C19H20N2O3S•HCl and molecular weight of 392.90 daltons 1.

Available Formulations

Pioglitazone is available as oral tablets in three strengths:

  • 15 mg (as the base)
  • 30 mg (as the base)
  • 45 mg (as the base)

The tablets contain pioglitazone formulated with lactose monohydrate, hydroxypropylcellulose, carboxymethylcellulose calcium, and magnesium stearate 1.

Mechanism of Action

Pioglitazone functions as a potent agonist for peroxisome proliferator-activated receptor-gamma (PPARγ), decreasing insulin resistance in peripheral tissues and the liver. This results in increased insulin-dependent glucose disposal and decreased hepatic glucose output 1. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue and requires the presence of endogenous insulin for its therapeutic effect 1.

References

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