Is pork tenderloin from a reliable source safe to eat when cooked medium-rare?

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From the Guidelines

Pork tenderloin from a reliable source is not safe to eat medium-rare, as the most recent and highest quality studies recommend cooking pork to an internal temperature of 165°F (73.8°C) to minimize the risk of foodborne illnesses, particularly for immunocompromised individuals 1.

Key Considerations

  • The risk of trichinosis and other foodborne pathogens is still present in undercooked pork, and cooking to a higher internal temperature is necessary to ensure safety.
  • The USDA and other health organizations recommend cooking pork to an internal temperature of 165°F (73.8°C) to minimize the risk of foodborne illnesses.
  • Handling and storing raw meat safely, as well as preventing cross-contamination with other foods, are crucial to reducing the risk of foodborne illnesses.

Recommendations

  • Cook pork tenderloin to an internal temperature of 165°F (73.8°C) to ensure safety.
  • Use a food thermometer to verify the internal temperature, especially when cooking to a specific temperature.
  • Handle raw meat safely, and prevent cross-contamination with other foods to reduce the risk of foodborne illnesses.
  • Always purchase pork from reputable sources to minimize the risk of contamination.

Important Notes

  • While some studies may suggest that cooking pork to medium-rare (145°F or 63°C) is safe, the most recent and highest quality studies recommend cooking to a higher internal temperature to minimize the risk of foodborne illnesses 1.
  • Immunocompromised individuals, such as those with HIV/AIDS, should take extra precautions when handling and consuming food to reduce the risk of foodborne illnesses.

From the Research

Safety of Eating Medium-Rare Pork Tenderloin

  • The safety of eating medium-rare pork tenderloin from a reliable source depends on the risk of trichinosis, a disease caused by the parasite Trichinella spp. 2, 3
  • Trichinosis can be transmitted to humans through the ingestion of undercooked meat containing infective encysted larvae 2
  • However, the risk of trichinosis from pork tenderloin can be minimized if the meat is handled and cooked properly 3
  • Cooking pork to an internal temperature of at least 145°F (63°C) can kill Trichinella parasites and make the meat safe to eat 3
  • It is essential to note that medium-rare cooking may not be sufficient to kill all Trichinella parasites, especially if the meat is not cooked uniformly 3

Prevalence of Trichinosis

  • Trichinosis is a worldwide zoonotic disease, and its prevalence has decreased in Europe and the United States due to improved pork production and handling practices 3
  • However, trichinosis still occurs in some parts of the world, particularly in areas where wild game meats are consumed raw or undercooked 3
  • The disease can cause a range of symptoms, including diarrhea, febrile syndrome, myalgias, and eosinophilia, and can be severe in some cases 2, 4

Diagnosis and Treatment

  • Diagnosis of trichinosis can be made through clinical symptoms, epidemiological data, and laboratory tests, including muscle biopsy and serology 2, 4
  • Treatment of trichinosis typically involves antiparasitic medications and supportive care, and prompt treatment can help prevent severe complications 4
  • It is crucial to handle and cook pork tenderloin safely to minimize the risk of trichinosis, especially for individuals who are at high risk of severe disease 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Trichinosis.

Brain pathology (Zurich, Switzerland), 1997

Research

[Neurologic manifestations in trichinosis].

Srpski arhiv za celokupno lekarstvo, 1998

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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