From the Research
The current literature suggests that a daily dose of 20 grams of creatine monohydrate, potentially divided into 2-4 smaller doses, may be beneficial for patients with Alzheimer's disease, as evidenced by improved cognition and increased brain total creatine levels 1. When considering the use of creatine in Alzheimer's disease, it's essential to look at the most recent and highest quality studies. The study by 1 published in 2025, which investigated the feasibility of 20 g/day creatine monohydrate for 8 weeks in 20 patients with Alzheimer's disease, found that serum creatine was elevated and brain total creatine increased by 11%, with improvements in cognition. Some key points to consider when implementing creatine supplementation for Alzheimer's disease include:
- Starting with a lower dose and gradually increasing as tolerated
- Dividing the daily dose into 2-4 smaller doses to maintain consistent blood levels and potentially improve cellular uptake
- Taking creatine with carbohydrates or protein to enhance absorption
- Monitoring patients for potential gastrointestinal side effects and adjusting the dosage regimen accordingly It's crucial to note that while creatine shows promise for supporting brain energy metabolism in neurodegenerative conditions like Alzheimer's disease, the evidence for its efficacy specifically in Alzheimer's remains preliminary, and patients should discuss this supplement with their healthcare provider before beginning treatment, especially if they have kidney problems or are taking other medications 1.