From the Research
Creatine supplementation is safe for individuals with Alzheimer's dementia and may have potential cognitive benefits, as evidenced by a recent pilot study showing improved cognition and increased brain total creatine levels 1. The most recent and highest quality study, published in 2025, investigated the feasibility of creatine monohydrate supplementation in patients with Alzheimer's disease and found that it was associated with increased brain total creatine and improvements in cognition 1. Key findings from this study include:
- Increased brain total creatine levels by 11% (p < 0.001)
- Improved cognition on global and fluid composites, List Sorting, Oral Reading, and Flanker tests
- High compliance rate, with 19 out of 20 participants achieving the target of ≥80% compliance with the creatine monohydrate intervention While the evidence is still preliminary, the potential benefits of creatine supplementation for individuals with Alzheimer's dementia, including improved cognitive function and increased brain total creatine levels, make it a worthwhile consideration for those seeking to support their brain health alongside conventional treatments 1. It is essential for individuals with Alzheimer's to consult their healthcare provider before starting creatine supplementation, particularly if they have kidney problems, as creatine is processed through the kidneys. A typical dosage of 3-5 grams of creatine monohydrate daily, taken with water or mixed into food, may be recommended, with no special timing required, though consistency helps maintain tissue levels 2, 3. Overall, the current evidence suggests that creatine supplementation is safe and may have potential cognitive benefits for individuals with Alzheimer's dementia, making it a promising area for further research 1.