Does pubic hair initially appear as fine, lightly pigmented vellus hair before maturing into terminal hair?

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Da, pubična dlakavost prvo počinje sa velusnim dlakama

Androgeni uzrokuju transformaciju velusnih (finih, mekih, nepigmentisanih) dlaka u terminalne dlake u androgen-zavisnim oblastima rasta dlaka, uključujući pubičnu regiju 1, 2.

Normalan proces razvoja pubične dlakavosti

Tokom puberteta, androgeni stimulišu folikule dlaka u pubičnoj regiji da prođu kroz specifičnu transformaciju:

  • Početna faza: Velusne dlake su prisutne pre puberteta - to su fine, meke, nepigmentirane dlake prečnika manjeg od 0.03 mm 3
  • Androgena stimulacija: Kada nivo androgena poraste tokom puberteta, oni deluju na dermalne papile folikula dlaka
  • Konverzija: Androgeni indukuju velusne folikule u polno-specifičnim oblastima da se razviju u terminalne folikule koji proizvode veće, pigmentirane dlake 1, 2

Mehanizam transformacije

Proces je androgen-zavisan i uključuje:

  • Vezivanje androgena (testosteron i dihidrotestosteron) za intracelularne androgene receptore u dermalnim papilama folikula dlaka 4
  • Enzim 5-alfa reduktaza konvertuje testosteron u dihidrotestosteron (DHT) unutar folikula 1
  • Ova hormonska stimulacija menja veličinu dermalne papile, aktivnost keratinocita i melanocita, i produžava fazu rasta dlake 5, 6

Klinički značaj

Ova transformacija je normalan deo pubertetskog razvoja i dešava se kod oba pola, mada sa različitim obrascima distribucije. Ako se pubična dlakavost razvija pre 8. godine kod devojčica, to se naziva preuranjena pubarha i zahteva evaluaciju za moguću preuranjenu adrenarhu ili druge endokrine poremećaje 7.

Važno je razlikovati normalnu hormonalnu dlakavost (hirsutizam kod žena) od nehormonal ne generalizovane dlakavosti (hipertrihoze), jer hirsutizam uvek uključuje transformaciju velusnih u terminalne dlake pod uticajem androgena 1.

References

1
Guideline

american association of clinical endocrinologists medical guidelines for the clinical practice for the diagnosis and treatment of hyperandrogenic disorders.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologist, 2001

4
Research

Hormonal Effects on Hair Follicles.

International journal of molecular sciences, 2020

5
Research

Androgens and hair growth.

Dermatologic therapy, 2008

7
Research

Approach to the girl with early onset of pubic hair.

The Journal of clinical endocrinology and metabolism, 2011

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