Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 9, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Abdominal Pain and Diarrhea after Gallbladder Removal

Single Most Likely Diagnosis

  • Postcholecystectomy Syndrome (PCS): This condition occurs in a significant number of patients after gallbladder removal and can cause abdominal pain, diarrhea, and other gastrointestinal symptoms due to various factors such as bile duct injury, retained stones, or sphincter of Oddi dysfunction.

Other Likely Diagnoses

  • Bile Salt Diarrhea: After gallbladder removal, the body may have difficulty regulating bile salts, leading to their accumulation in the colon and causing diarrhea.
  • Gastroesophageal Reflux Disease (GERD): The absence of a gallbladder can lead to changes in bile flow, potentially exacerbating or triggering GERD symptoms, including abdominal pain and diarrhea.
  • Irritable Bowel Syndrome (IBS): Changes in bowel habits and abdominal pain can sometimes be attributed to IBS, especially if other causes are ruled out.
  • Small Intestine Bacterial Overgrowth (SIBO): This condition can cause abdominal pain, bloating, and diarrhea, and its incidence might be increased after gallbladder surgery due to altered intestinal motility and anatomy.

Do Not Miss Diagnoses

  • Bile Duct Injury or Leak: A serious complication of gallbladder surgery that can lead to severe abdominal pain, infection, and potentially life-threatening conditions if not promptly addressed.
  • Retained Common Duct Stones: Stones left behind in the bile ducts during surgery can cause obstructive jaundice, abdominal pain, and potentially lead to infection or pancreatitis.
  • Sphincter of Oddi Dysfunction: Abnormal function of the sphincter of Oddi, which regulates bile and pancreatic juice flow, can cause recurrent abdominal pain and may mimic other conditions.

Rare Diagnoses

  • Chron's Disease or Ulcerative Colitis: Although less common, inflammatory bowel diseases can be triggered or worsened by changes in the gastrointestinal environment post-surgery.
  • Pancreatitis: Inflammation of the pancreas can occur due to various reasons post-gallbladder removal, including bile duct injury or sphincter of Oddi dysfunction, and requires immediate medical attention.
  • Intestinal Obstruction: Adhesions or other complications from surgery can lead to bowel obstruction, causing severe abdominal pain, vomiting, and constipation rather than diarrhea, but it's a critical condition to consider.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.