What is the recommended dose of Augmentin (amoxicillin-clavulanate) for a 19-year-old female?

From the Guidelines

The recommended dose of Augmentin (amoxicillin-clavulanate) for a 19-year-old female is 875 mg/125 mg taken orally every 12 hours. This dosage is based on the most recent and highest quality study available, which is the 2014 update by the Infectious Diseases Society of America 1. The specific dosage depends on the severity of the infection being treated, with the 875 mg formulation twice daily being recommended for more severe infections.

Key Considerations

• The duration of treatment generally ranges from 7 to 14 days, depending on the type of infection.
• It's essential to take Augmentin with food to reduce gastrointestinal side effects and enhance absorption.
• The patient should complete the entire prescribed course, even if symptoms improve before finishing the medication.
• Augmentin works by combining amoxicillin, which kills bacteria by inhibiting cell wall synthesis, with clavulanate, which protects amoxicillin from degradation by beta-lactamase enzymes that some bacteria produce.
• Common side effects include diarrhea, nausea, and skin rash, and the patient should contact their healthcare provider if severe side effects occur.

Evidence-Based Recommendations

The recommended dosage of 875 mg/125 mg every 12 hours is supported by the 2014 guidelines, which provide evidence-based recommendations for the treatment of skin and soft tissue infections 1. These guidelines recommend amoxicillin-clavulanate as a first-line treatment option for certain types of infections, including those caused by streptococci, S. aureus, and Eikenella corrodens.

Important Notes

• The bacteriology of wounds can differentiate the number of isolates per wound and whether additional coverage for anaerobes is required.
• Cultures are often not done on wounds, and empirical therapy might miss pathogens.
• Broader empirical coverage for abscesses might yield better therapeutic results, while a more focused therapy for nonpurulent infected wounds could allow narrower therapy.

From the FDA Drug Label

DOSAGE AND ADMINISTRATION Adults The usual adult dose is one amoxicillin and clavulanate potassium tablet USP, 500 mg/125 mg every 12 hours or one amoxicillin and clavulanate potassium tablet USP, 250 mg/125 mg every 8 hours For more severe infections and infections of the respiratory tract, the dose should be one amoxicillin and clavulanate potassium tablet USP, 875 mg/125 mg every 12 hours or one amoxicillin and clavulanate potassium tablet USP, 500 mg/125 mg every 8 hours.

The recommended dose of Augmentin for a 19-year-old female is:

• 500 mg/125 mg every 12 hours
• 250 mg/125 mg every 8 hours For more severe infections, the dose can be increased to 875 mg/125 mg every 12 hours or 500 mg/125 mg every 8 hours 2.

From the Research

Augmentin Dose for a 19-Year-Old Female

The recommended dose of Augmentin (amoxicillin-clavulanate) can vary depending on the specific infection being treated. Based on the available studies:

• For the treatment of acute bacterial maxillary sinusitis, a dose of 875 mg amoxicillin and 125 mg clavulanate every 12 hours is considered effective 3.
• There is no specific dose recommendation provided in the studies for a 19-year-old female. However, the standard dose for adults is typically 500 mg to 875 mg every 8 to 12 hours 4, 3.
• It's essential to note that the dose and duration of treatment should be determined by a healthcare professional based on the individual's specific condition and medical history.

Key Considerations

• The studies provided do not specifically address the dosage for a 19-year-old female, but they do offer insight into the effective doses for various infections in adults and children.
• Amoxicillin-clavulanate is a commonly used antibiotic for treating a range of bacterial infections, including respiratory tract infections, skin and soft tissue infections, and urinary tract infections.
• The choice of dose and treatment duration should always be guided by a healthcare professional to ensure effective treatment and minimize the risk of adverse effects.

Available Dosage Information

• Study 3 compares the efficacy of amoxicillin-clavulanate given every 12 hours versus every 8 hours for the treatment of acute bacterial maxillary sinusitis in adults.
• Study 4 mentions the use of amoxicillin-clavulanate in the treatment of acute ear, nose, and throat infections, but does not provide specific dosage information for adults.
• Other studies 5, 6, 7 discuss the efficacy and safety of amoxicillin-clavulanate in various infections, but do not provide specific dosage recommendations for a 19-year-old female.