From the Research
Fertility typically returns after completing a course of Myfembree for endometriosis, but there may be a delay. Myfembree, which contains relugolix, estradiol, and norethindrone acetate, works by suppressing ovarian function and intentionally reduces fertility during treatment. After stopping the medication, most women will regain their fertility within a few months, though it can take up to a year for some individuals. The exact time frame can vary depending on factors such as age, overall health, and the duration of treatment. It's essential to note that while Myfembree is not intended for long-term use, it doesn't cause permanent infertility. However, if you're planning to conceive, it's crucial to discuss your fertility goals with your healthcare provider before stopping the medication. They may recommend waiting for a certain period after discontinuation before attempting to conceive, to ensure hormone levels have normalized and to optimize your chances of a healthy pregnancy.
Factors Affecting Fertility Return
Some key factors that can influence the return of fertility after stopping Myfembree include:
- Age: Older women may take longer to regain fertility
- Overall health: Women with underlying health conditions may experience delays in fertility return
- Duration of treatment: Longer treatment durations may lead to longer recovery times
According to the most recent study 1, dienogest and leuprolide were found to be effective in improving pregnancy rates after fertility-preserving surgery for endometriosis. However, it's essential to note that this study focused on subsequent therapies after surgery, not specifically on Myfembree. Nevertheless, the findings suggest that hormonal therapies can have a positive impact on fertility outcomes.
Importance of Healthcare Provider Guidance
It's crucial to consult with a healthcare provider before stopping Myfembree, especially if you're planning to conceive. They can provide personalized guidance on the best course of action, taking into account your individual circumstances and medical history. By working closely with your healthcare provider, you can optimize your chances of a healthy pregnancy and minimize potential risks.
In terms of fertility preservation, studies have shown that techniques such as embryo, oocyte, and ovarian tissue cryopreservation can be effective for patients with endometriosis 2. However, these methods may not be necessary for women taking Myfembree, as the medication is not intended for long-term use and does not cause permanent infertility. Nevertheless, it's essential to discuss fertility preservation options with your healthcare provider if you're concerned about your fertility.