From the Guidelines
The ADMA (Asymmetric Dimethylarginine) lab test is a blood test that measures the levels of a naturally occurring compound in the blood that can inhibit nitric oxide production in the body. This test is primarily used to assess cardiovascular risk and endothelial dysfunction. ADMA works by blocking the enzyme nitric oxide synthase, which is responsible for producing nitric oxide, a molecule that helps blood vessels dilate and maintain healthy function. Elevated ADMA levels are associated with various cardiovascular conditions including hypertension, atherosclerosis, heart failure, and chronic kidney disease. The test requires a simple blood draw and is typically ordered as part of a cardiovascular risk assessment, especially in patients with existing heart disease, kidney problems, or multiple risk factors. Normal ADMA levels generally range from 0.4 to 0.8 μmol/L, though reference ranges may vary between laboratories. If elevated levels are found, your doctor might recommend lifestyle modifications, medications to improve cardiovascular health, or further testing to identify underlying causes. The test helps clinicians understand the state of your vascular health at a molecular level, providing insights beyond traditional cardiovascular risk factors. It's worth noting that the provided evidence does not directly discuss ADMA, but based on general medical knowledge, the above explanation is provided 1.
From the Research
What is an ADMA Lab Test
- An ADMA lab test measures the level of asymmetric dimethylarginine (ADMA) in the blood 2, 3, 4, 5, 6.
- ADMA is a substance that can block the production of nitric oxide (NO) in the body, which can lead to endothelial dysfunction and increase the risk of cardiovascular disease 2, 3, 4, 5, 6.
How ADMA Affects the Body
- High levels of ADMA in the blood have been linked to an increased risk of cardiovascular events, such as heart attacks and strokes 2, 4, 6.
- ADMA can also contribute to the development of endothelial dysfunction, which can lead to high blood pressure, atherosclerosis, and other cardiovascular problems 2, 3, 5.
What the Test Results Mean
- Elevated levels of ADMA in the blood may indicate an increased risk of cardiovascular disease 2, 4, 5, 6.
- The test results can be used to help diagnose and monitor cardiovascular disease, as well as to assess the effectiveness of treatments aimed at reducing ADMA levels and improving cardiovascular health 2, 3, 6.