From the Research
Nicotinamide Mononucleotide (NMN) supplementation is recommended for healthy adults, with a typical dosage of 250-1000mg daily, taken orally, to boost NAD+ levels and potentially improve age-related diseases, based on the most recent and highest quality study available 1.
Key Considerations
- NMN should be stored in a cool, dry place and is often recommended to be taken in the morning with or without food.
- The supplement works by boosting NAD+ levels in the body, a coenzyme critical for cellular energy production and repair that naturally declines with age.
- While animal studies suggest potential benefits for longevity, metabolism, and cognitive function, human evidence remains preliminary.
- Side effects appear minimal but may include mild gastrointestinal discomfort, insomnia if taken late in the day, and potential interactions with medications.
Important Precautions
- Those with medical conditions, pregnant or nursing women, and individuals taking other medications should consult healthcare providers before starting NMN.
- As a relatively expensive supplement without FDA approval for specific health claims, consumers should approach NMN with realistic expectations and consider it as part of a broader health strategy rather than a standalone anti-aging solution.
Recent Study Findings
- A 2024 study published in the Mechanisms of ageing and development journal found that NMN supplementation increased NAD+ concentration in a dose-dependent manner, with a significant improvement in walking distance and quality of life scores 1.
- Another 2024 study published in the Endocrine journal found that NMN supplementation was well-tolerated and increased NAD+ levels in peripheral blood mononuclear cells, with potential benefits for postprandial hyperinsulinemia 2.