From the Research
The current scientific evidence does not support recommending NMN supplements specifically for cancer prevention or anti-aging purposes in humans, despite promising animal research. NMN is a precursor to NAD+ (nicotinamide adenine dinucleotide), a molecule that declines with age and is involved in many cellular processes including DNA repair and energy metabolism. While animal studies, such as the one published in 2024 1, have shown some benefits including improved metabolism and potentially extended lifespan, these results haven't been conclusively demonstrated in humans.
Key Points to Consider
- The most recent and highest quality study on NMN supplementation in humans, published in 2024 2, found that NMN overall safely and effectively boosted NAD+ biosynthesis in healthy, middle-aged Japanese men, showing its potential for alleviating postprandial hyperinsulinemia.
- However, this study had a small sample size and was not designed to assess the effects of NMN on cancer prevention or aging.
- Other studies, such as those published in 2023 3 and 2022 4, have reviewed the current knowledge on the promises and safety concerns of NMN as an anti-aging health product, but have not provided conclusive evidence of its effectiveness in humans.
- A preclinical study published in 2024 5 reviewed the role and potential mechanisms of NMN in aging, but highlighted the need for more human clinical trials to determine its safety and efficacy.
Recommendations
- Instead of relying on unproven supplements, established approaches to cancer prevention and healthy aging include:
- Maintaining a balanced diet
- Regular exercise
- Adequate sleep
- Stress management
- Avoiding tobacco
- Limiting alcohol consumption
- Getting recommended cancer screenings
- These lifestyle factors have substantial evidence supporting their effectiveness in promoting longevity and reducing cancer risk, as noted in various studies 3, 4, 2, 5.