From the Guidelines
The most effective treatment for perioral rhytides is the use of autologous platelet concentrates, specifically platelet-rich plasma (PRP), which has been shown to improve lip rejuvenation, dermal structure, and moisture, with high patient satisfaction and natural-looking results. According to a recent study published in 2025 1, PRP was found to be an effective option for lip rejuvenation, with improvements in color, dermal structure, and moisture. Another study published in the same year 1 also demonstrated the efficacy of PRP in reducing superficial perioral wrinkles and restoring dermal matrix, with significant improvements in moisture, collagen fibers, and skin elasticity.
Key Findings
- PRP has been shown to improve lip rejuvenation, with high patient satisfaction and natural-looking results 1
- PRP can improve dermal structure and moisture, reducing superficial perioral wrinkles and restoring dermal matrix 1
- The use of PRP is a safe and cost-effective method for lip rejuvenation, with minimal side effects 1
Treatment Approach
- PRP injections can be used to improve lip rejuvenation and reduce perioral rhytides
- Topical PRP can also be used to reduce superficial perioral wrinkles and restore dermal matrix
- Combination therapy with other treatments, such as botulinum toxin injections or dermal fillers, may be considered for more comprehensive improvement
Important Considerations
- The longevity of the effects of PRP needs to be studied further 1
- Large, multi-center studies are required to confirm the preliminary results of PRP for lip rejuvenation 1
From the Research
Treatment Options for Perioral Rhytides
- Various treatment options exist for perioral rhytides, including neurotoxin, filler, microneedling, fractional resurfacing, and fully ablative lasers, as well as deep chemical peels 2
- A combination approach, taking into account the patient's treatment goals and expected downtime, is often proposed as the best approach 2
- Injectable fillers, such as small-particle hyaluronic acid filler (SP-HAL) and cohesive polydensified matrix hyaluronic acid filler (CPM-HA), have been shown to be effective in reducing perioral rhytid severity, with SP-HAL possessing a longer duration of effect 3
- Resurfacing procedures, including chemical peels, dermabrasion, and laser resurfacing, can also be used to rejuvenate the perioral area, with the best outcomes often achieved using a combination of these modalities tailored to each patient's needs 4
Botulinum Toxin A Treatment
- Botulinum toxin A has been used to treat perioral rhytides, resulting in smoothening of hyperfunctional lines and upper lip fullness/eversion, with 72% of patients continuing treatment 5
- While botulinum toxin A is more commonly used to treat dynamic facial rhytides of the upper face, it has been shown to be effective in treating perioral rhytides, with added cosmetic benefits of lip eversion and enhanced lip fullness 5
Combination Treatment
- Combination treatment with botulinum toxin A and hyaluronic acid filler has been shown to be effective in treating forehead and glabellar lines, with longer-lasting results and greater wrinkle reduction compared to botulinum toxin A alone 6
- However, it is worth noting that the study on combination treatment was focused on forehead and glabellar lines, and not specifically on perioral rhytides 6