What is the recommended protocol for tapering off citalopram (SSRI) 20mg?

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From the Guidelines

The recommended protocol for tapering off citalopram 20mg is a gradual reduction over 2-4 weeks or longer, depending on how long you've been taking the medication, to minimize the risk of discontinuation syndrome and other adverse effects. When considering tapering off citalopram, it's essential to take into account the potential for discontinuation syndrome, which can be characterized by symptoms such as dizziness, fatigue, lethargy, and anxiety 1. A common approach to tapering off citalopram is to reduce the dose by 5mg every 1-2 weeks, for example, going from 20mg to 15mg for 1-2 weeks, then to 10mg for 1-2 weeks, then 5mg for 1-2 weeks before stopping completely. Some key points to consider when tapering off citalopram include:

  • The importance of gradual reduction to minimize the risk of discontinuation syndrome
  • The need to monitor for symptoms such as dizziness, nausea, headaches, and anxiety during the taper
  • The potential for some individuals to require a slower taper, especially if they've been on citalopram for an extended period
  • The importance of consulting with a healthcare provider before starting a taper, as they may recommend a personalized schedule based on individual circumstances 1. It's also crucial to note that citalopram can cause QT prolongation associated with Torsade de Pointes, ventricular tachycardia, and sudden death at daily doses exceeding 40 mg/d, and should be avoided in patients with long QT syndrome 1. Ultimately, the goal of tapering off citalopram is to allow the brain to adjust to decreasing levels of serotonin while minimizing the risk of adverse effects, and this should be done under the guidance of a healthcare provider.

From the Research

Tapering Off Citalopram

To taper off citalopram 20mg, it is essential to follow a recommended protocol to minimize withdrawal symptoms.

  • The tapering process should be done slowly and hyperbolically, reducing the dose to minimize the effect on serotonin transporter inhibition in a linear manner 2.
  • Guidelines recommend tapering over a period of months, rather than the traditional 2-4 weeks, to reduce withdrawal symptoms 2.
  • Reducing the dose to lower than the minimum therapeutic dose before complete cessation is also recommended 2.

Recommended Tapering Protocol

  • There is no one-size-fits-all tapering protocol, but a hyperbolic tapering program can be effective in reducing withdrawal symptoms 2.
  • The protocol should be individualized, taking into account the patient's medical history, current dose, and response to tapering 2.
  • It is crucial to monitor the patient's symptoms and adjust the tapering schedule as needed to minimize withdrawal symptoms 2.

Importance of Slow Tapering

  • Slow tapering is essential to minimize the risk of withdrawal symptoms, which can be severe and compel patients to recommence their medication 2.
  • Abrupt discontinuation or rapid tapering can lead to withdrawal symptoms, which can be mistaken for recurrence of the underlying disorder 2.
  • A slow and hyperbolic tapering protocol can help reduce the risk of withdrawal symptoms and ensure a successful discontinuation of citalopram 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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