Is topical ivermectin effective for treating skin cancer?

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Last updated: June 11, 2025View editorial policy

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From the Guidelines

Topical ivermectin is not effective for treating skin cancer. Ivermectin is an antiparasitic medication primarily used to treat conditions like rosacea, scabies, and certain parasitic infections, but it has no proven efficacy against any form of skin cancer. Skin cancers (including basal cell carcinoma, squamous cell carcinoma, and melanoma) require established medical treatments such as surgical excision, Mohs surgery, radiation therapy, topical chemotherapy agents (like 5-fluorouracil or imiquimod for certain superficial cancers), or systemic treatments for advanced cases.

Key Points to Consider

  • These cancers develop due to DNA damage and abnormal cell growth mechanisms that are not affected by ivermectin's mechanism of action, which works by paralyzing parasites through disruption of their nervous systems.
  • According to the guidelines of care for the management of basal cell carcinoma 1, topical therapies such as imiquimod and 5-fluorouracil are effective for treating superficial basal cell carcinoma, but there is no mention of ivermectin as a treatment option.
  • The NCCN clinical practice guidelines in oncology 1 also recommend imiquimod and 5-fluorouracil as topical therapies for basal cell carcinoma, but do not mention ivermectin.
  • If you suspect you have skin cancer, it's essential to consult a dermatologist promptly for proper diagnosis and evidence-based treatment rather than attempting to treat it with inappropriate medications like ivermectin.

Treatment Options

  • Established medical treatments for skin cancer include:
    • Surgical excision
    • Mohs surgery
    • Radiation therapy
    • Topical chemotherapy agents (like 5-fluorouracil or imiquimod for certain superficial cancers)
    • Systemic treatments for advanced cases
  • Topical therapies such as imiquimod and 5-fluorouracil are effective for treating superficial basal cell carcinoma, as shown in studies 1.

From the Research

Topical Ivermectin for Skin Cancer

  • There are no research papers to assist in answering this question, as the provided studies do not investigate the effectiveness of topical ivermectin for treating skin cancer 2, 3, 4, 5.
  • The studies focus on other treatments for skin cancer, such as photodynamic therapy, cryotherapy, 5-fluorouracil, and imiquimod 2, 3, 4, 5.
  • One study investigates the use of topical ivermectin for papulopustular rosacea, but not for skin cancer 6.
  • Therefore, there is no evidence to support the use of topical ivermectin for treating skin cancer based on the provided studies.

Alternative Treatments for Skin Cancer

  • The provided studies discuss various alternative treatments for skin cancer, including:
    • Photodynamic therapy 2, 3, 5
    • Cryotherapy 3, 5
    • 5-fluorouracil 2, 3, 4, 5
    • Imiquimod 2, 3, 4, 5
  • These treatments have shown varying degrees of effectiveness in treating different types of skin cancer, but topical ivermectin is not mentioned as a treatment option for skin cancer in the provided studies 2, 3, 4, 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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