ICU Delirium Care Smart Phrase
Implement routine delirium screening using CAM-ICU or ICDSC every shift, combined with a multicomponent non-pharmacological prevention bundle focused on early mobilization, sleep optimization, and family engagement. 1
Delirium Assessment Protocol
Screen all ICU patients for delirium ≥4 times per shift using validated tools:
- CAM-ICU (Confusion Assessment Method for ICU) - preferred
- ICDSC (ICU Delirium Screening Checklist) - alternative 1, 2
Document results in EHR each assessment. Positive screen triggers immediate intervention bundle.
Risk Factor Identification
Baseline risk factors to document:
- Pre-existing dementia
- History of hypertension
- History of alcoholism
- High severity of illness at admission 1
Modifiable risk factors to address:
- Coma (independent risk factor) 1
- Benzodiazepine use (strong association with delirium development) 1
- Immobility
- Sleep deprivation
- Sensory impairment (vision/hearing)
Prevention Bundle (Implement for ALL ICU Patients)
1. Sedation Management
- Avoid benzodiazepine infusions - use propofol or dexmedetomidine instead 1, 2
- Target light sedation (RASS 0 to -1) or implement daily sedation interruption 1
- Use analgesia-first approach - treat pain before sedating 1
2. Early Mobilization (HIGHEST PRIORITY)
Initiate mobilization as early as feasible to reduce delirium incidence and duration 1, 2
- Out-of-bed activities when hemodynamically stable
- Progressive mobility protocol each shift
- Physical therapy consultation within 24 hours of admission
3. Sleep Hygiene Protocol
- Minimize nighttime noise and light exposure
- Cluster care activities to protect sleep cycles
- Reduce stimuli between 22:00-06:00 1
- Avoid unnecessary nighttime vital signs/procedures
4. Cognitive/Sensory Optimization
- Reorientation strategies (clocks, calendars, windows)
- Ensure hearing aids and eyeglasses available and functioning
- Cognitive stimulation activities
- Family presence and engagement 2, 3, 4
Pharmacological Considerations
Prevention
DO NOT use prophylactic antipsychotics (haloperidol or atypical antipsychotics) to prevent delirium 1, 2
Sedation in At-Risk Patients
- Prefer dexmedetomidine over benzodiazepines in mechanically ventilated patients at risk for delirium 1
- Exception: alcohol or benzodiazepine withdrawal (use benzodiazepines) 1
Treatment of Active Delirium
Non-Pharmacological (FIRST-LINE)
Continue/intensify prevention bundle above, with emphasis on:
- Identifying and treating underlying causes (infection, metabolic derangement, hypoxia)
- Removing deliriogenic medications
- Maximizing family presence 3, 4
Pharmacological Treatment
Antipsychotics:
- No evidence that haloperidol reduces delirium duration 1
- Atypical antipsychotics may reduce duration (weak evidence) 1
- Do NOT routinely use haloperidol or atypical antipsychotics 2
Contraindications to antipsychotics:
- Baseline QTc prolongation
- History of Torsades de Pointes
- Concurrent QT-prolonging medications 1
Dexmedetomidine:
- Use for agitated delirium when sedation needed AND agitation is preventing weaning/extubation 2
- Preferred over benzodiazepines for sedation in delirious patients (except ETOH/benzo withdrawal) 1
DO NOT use rivastigmine - increases mortality 1
Documentation Template
DELIRIUM ASSESSMENT:
□ CAM-ICU: [Positive/Negative]
□ Risk factors present: [list]
□ Prevention bundle implemented:
□ Light sedation target (RASS goal: ___)
□ Benzodiazepines avoided
□ Early mobilization: [activity level]
□ Sleep hygiene measures active
□ Sensory aids in place
□ Family engagement: [details]
IF DELIRIUM PRESENT:
□ Underlying causes addressed: [list interventions]
□ Deliriogenic medications reviewed/discontinued
□ QTc checked if antipsychotic considered: ___ ms
□ Sedation strategy: [dexmedetomidine/other/none]Key Pitfalls to Avoid
- Never skip delirium screening - it remains underdiagnosed despite validated tools 5, 6
- Benzodiazepines are NOT first-line sedation in ICU patients at risk for delirium 1, 2
- Antipsychotics are NOT for prevention and have limited evidence for treatment 1, 2
- Immobility is modifiable - early mobilization has strongest evidence for prevention 1, 2
- Check QTc before any antipsychotic administration 1
Clinical Significance
Delirium is associated with:
- Increased mortality 1
- Prolonged ICU and hospital length of stay 1
- Post-ICU cognitive impairment 1
- Long-term psychological burden 7, 5
The most effective interventions are non-pharmacological and require coordinated multidisciplinary implementation 2, 7, 3, 4