From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
The best way to taper off Seroquel (quetiapine) 75mg at bedtime is to follow a gradual reduction plan, reducing the dose by one quarter (or one half) of the most recent dose, equivalent to a reduction of 5 (or 10) percentage points of its D2 blockade, sequentially, at intervals of 3-6 months, titrated to individual tolerance, as suggested by the most recent and highest quality study 1.
Tapering Plan
When tapering off Seroquel, it's essential to work with your healthcare provider to determine the best approach for your individual needs. The goal is to minimize withdrawal symptoms, which can include insomnia, nausea, headache, anxiety, and irritability.
- Reduce the dose gradually, allowing your brain chemistry to adjust to the changes.
- Maintain regular sleep habits and practice good sleep hygiene during the tapering process.
- Consider non-medication approaches, such as relaxation techniques, to help with sleep and anxiety.
Importance of Gradual Reduction
Never stop Seroquel abruptly, as this can cause more severe withdrawal effects and potential rebound symptoms of the original condition being treated. The gradual reduction approach allows your brain chemistry to slowly readjust to functioning without the medication, as Seroquel works by affecting neurotransmitters like dopamine and serotonin that regulate mood and sleep.
Monitoring and Adjustment
If you experience troublesome withdrawal symptoms, contact your healthcare provider immediately, as your tapering schedule may need adjustment. It's crucial to prioritize your individual tolerance and adjust the tapering plan accordingly.
Evidence-Based Recommendation
The recommended tapering plan is based on the most recent and highest quality study 1, which suggests a gradual reduction approach to minimize the risk of relapse and withdrawal symptoms. This approach is supported by the latest research and guidelines, ensuring the best possible outcome for patients tapering off Seroquel.