Differential Diagnosis for AKI

Given the patient's eGFR of 49 and creatinine level of 1.30, we can consider the following differential diagnoses:

• Single most likely diagnosis
  • Chronic Kidney Disease (CKD): The patient's eGFR is below 60, which is a criterion for CKD. The creatinine level is also elevated, suggesting impaired kidney function. This diagnosis is likely given the chronic nature of the kidney disease.
• Other Likely diagnoses
  • Acute on Chronic Kidney Injury: The patient's elevated creatinine level could indicate an acute injury superimposed on chronic kidney disease.
  • Dehydration: Dehydration can cause a rise in creatinine levels, which may be reversible with fluid resuscitation.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Obstructive Uropathy: Although less likely, obstructive uropathy can cause acute kidney injury and is a medical emergency that requires prompt intervention.
  • Vasculitis: Conditions like vasculitis can cause kidney injury and are important to consider, as they require specific treatment.
  • Sepsis: Sepsis can cause acute kidney injury, and it is crucial to identify and treat promptly to prevent mortality.
• Rare diagnoses
  • Glomerulonephritis: This is an inflammatory condition that can cause kidney injury, but it is less common and may require specific diagnostic tests.
  • Interstitial Nephritis: This condition can cause kidney injury, but it is relatively rare and may be associated with specific medications or infections.
  • Myeloma Kidney: This condition is associated with multiple myeloma and can cause kidney injury, but it is relatively rare and may require specific diagnostic tests.