From the Research
Inositol is generally considered safe during pregnancy when taken in appropriate doses, though pregnant women should consult with their healthcare provider before starting any supplement. Inositol occurs naturally in the body and in many foods, with two common forms being myo-inositol and D-chiro-inositol. For pregnant women, particularly those with gestational diabetes or polycystic ovary syndrome (PCOS), myo-inositol supplementation (typically 2-4 grams daily) has shown potential benefits in improving insulin sensitivity and reducing gestational diabetes risk, as supported by a recent review 1. Some studies suggest it may also help prevent gestational hypertension and preeclampsia.
The most recent and highest quality study on this topic, a systematic review and meta-analysis published in 2023, found that myo-inositol supplementation may reduce the incidence of gestational diabetes, hypertensive disorders of pregnancy, and preterm birth 2. The study included seven randomized controlled trials and found that myo-inositol supplementation was associated with a lower risk of gestational diabetes (risk ratio 0.53,95% confidence interval 0.31 to 0.90) and hypertensive disorders of pregnancy (risk ratio 0.34,95% confidence interval 0.19 to 0.61).
Key points to consider when evaluating the safety and efficacy of inositol supplementation during pregnancy include:
- The natural occurrence of inositol in the body and in many foods, making moderate supplementation generally well-tolerated
- The potential benefits of myo-inositol supplementation in improving insulin sensitivity and reducing gestational diabetes risk
- The importance of consulting with a healthcare provider before starting any supplement, particularly for pregnant women with gestational diabetes or PCOS
- The need for further studies to confirm the efficacy and safety of inositol supplementation during pregnancy, particularly in diverse populations and with varying doses and durations of supplementation.
Side effects of inositol supplementation are usually mild and may include nausea, gas, or diarrhea at higher doses, as reported in previous studies 3, 4, 5. However, the current evidence suggests that inositol supplementation is safe and may be beneficial for pregnant women, particularly those at risk of gestational diabetes. Pregnant women should consult with their healthcare provider before starting any supplement to determine the best course of treatment for their individual needs.