From the Research
BPC 157 (Body Protection Compound 157) currently lacks sufficient high-quality clinical evidence to recommend its use in humans, and patients should exercise caution and consult healthcare providers before considering it, as optimal dosing, administration routes, safety profiles, and long-term effects in humans remain largely unknown 1, 2.
Current Evidence
The current evidence for BPC 157 is mostly based on animal studies, which suggest potential benefits for tissue healing, gut protection, and anti-inflammatory effects. However, human clinical trials are limited and inconclusive. A recent pilot study published in 2025 found that intravenous infusion of BPC 157 was safe and well-tolerated in two healthy adults, with no measurable effects on biomarkers of the heart, liver, kidneys, thyroid, or blood glucose levels 1. Another study published in 2025 reviewed the multifunctionality and possible medical application of BPC 157, highlighting its potential benefits and safety profile, but also noting the lack of comprehensive clinical studies confirming its health benefits in humans 2.
Mechanisms and Potential Benefits
The mechanisms of BPC 157 may involve promoting angiogenesis, modulating growth factors, and reducing inflammation, which could help with tendon, muscle, and nerve healing. However, the optimal dosing, administration routes, safety profiles, and long-term effects in humans remain largely unknown. Some studies suggest that BPC 157 may have a beneficial effect on musculoskeletal soft tissue healing, including tendon, ligament, and skeletal muscle healing, but these findings are based on animal models and need to be confirmed in humans 3, 4.
Safety and Efficacy
The safety and efficacy of BPC 157 in humans are not well established, and more research is needed to fully understand its potential benefits and risks. While some studies report no adverse reactions to BPC 157, others note that the compound's safety profile is not fully understood, and long-term effects are unknown 5, 4. The FDA has not approved BPC 157 for any medical condition, and it is primarily sold as a research chemical or supplement.
Recommendations
Given the limited and inconclusive evidence, patients should exercise caution and consult healthcare providers before considering BPC 157. Current use represents experimental self-treatment with significant unknowns regarding purity of commercially available products, potential side effects, and interactions with medications or medical conditions. Healthcare providers should carefully weigh the potential benefits and risks of BPC 157 and consider alternative treatments that have a more established safety and efficacy profile.