From the Research
Olmesartan is unlikely to cause eye symptoms, and in fact, may have a protective effect on the eyes, as suggested by a study where it inhibited the progression of cataract formation in hypertensive rats. Some patients taking this angiotensin II receptor antagonist may experience blurred vision, eye pain, or changes in vision, but these ocular side effects are not among the most frequently reported adverse reactions for olmesartan, which is primarily prescribed at doses of 20-40 mg daily for hypertension management 1. If you develop any eye symptoms while taking olmesartan, you should contact your healthcare provider promptly rather than discontinuing the medication on your own. The mechanism behind these eye effects isn't fully understood but may relate to changes in blood flow to ocular tissues or direct effects on angiotensin receptors in the eye. Olmesartan works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow, and since blood vessels supply the eyes, changes in vascular tone could potentially affect vision.
Key Points to Consider
- Olmesartan may have a protective effect on the eyes, as suggested by a study where it inhibited the progression of cataract formation in hypertensive rats 1.
- The most recent and highest quality study available on this topic is from 2016, which found that olmesartan potentially inhibits the risk of cataract formation in the hypertensive state via restoration of lenticular oxidative stress, ATPase function, and ionic contents in the eye lenses 1.
- Other studies have focused on the antihypertensive effects of olmesartan, its comparison with other angiotensin receptor blockers, and its effects on cerebral blood flow, but these do not directly address the question of eye symptoms 2, 3, 4, 5.
- It is essential to prioritize the single most recent and highest quality study when making a definitive recommendation, which in this case is the 2016 study on olmesartan's effects on cataract formation 1.
Recommendations for Patients
- If you are taking olmesartan and experience any eye symptoms, contact your healthcare provider promptly.
- Do not discontinue olmesartan without consulting your healthcare provider, as this may lead to uncontrolled hypertension and other complications.
- Your doctor may consider alternative antihypertensive medications if eye symptoms become problematic, but this should be done under close medical supervision.