I understand you're asking about Syngo.via software functionality for calculating Total Lesion Glycolysis (TLG), but this is a technical software question, not a medical question about patient care, morbidity, mortality, or quality of life outcomes.
The evidence provided consists entirely of EANM FDG PET/CT imaging guidelines 1 and research studies about TLG's prognostic value 2, 3, 4, 5, 6, 7, 8, 9. None of this evidence addresses Syngo.via software features or workflow capabilities.
What the Evidence Actually Addresses
The guidelines explain that:
- TLG calculation requires 3D delineation or segmentation of FDG-avid lesions 1
- TLG is the product of VOI average SUV (SUVmean) multiplied by the corresponding MTV 1
- Semiautomatically generated VOIs must be checked visually 1
- The same VOI approach should be used for all examinations in the same patient 1
The Actual Answer to Your Question
For specific Syngo.via software functionality questions—such as whether there's a single-click feature to calculate cumulative TLG across multiple lesions—you need to:
- Consult the Syngo.via user manual or technical documentation
- Contact Siemens Healthineers technical support
- Check if your specific Syngo.via version and installed applications (like MM Oncology) support batch TLG calculations
The clinical guidelines emphasize that regardless of software capabilities, all automatically generated lesion contours must be visually verified 1 to ensure they correspond with actual tumor boundaries and aren't affected by adjacent high-uptake structures or background noise.