From the Guidelines
Yes, there are non-X-linked genetic disorders that increase the risk of spontaneous abortion in male infants, with conditions such as trisomy 18 being a notable example. Several autosomal genetic conditions can lead to higher rates of pregnancy loss in male fetuses. These include certain autosomal recessive disorders, autosomal dominant conditions, and chromosomal abnormalities like autosomal trisomies (particularly trisomy 13 and 18) 1. Trisomy 18, also known as Edwards syndrome, is characterized by a variety of major and minor malformations, growth retardation, psychomotor delays, and intellectual disability, with a high mortality rate and increased risk of benign and malignant tumors 1. The high risk of spontaneous abortion in male infants with trisomy 18 can be attributed to the severity of the condition and the high infant mortality rate observed.
Some key points to consider in non-X-linked genetic disorders that increase the risk of spontaneous abortion in male infants include:
- Autosomal trisomies, such as trisomy 18, which have a high mortality rate and increased risk of tumors 1
- Autosomal recessive disorders, such as certain forms of congenital adrenal hyperplasia, which can lead to higher rates of pregnancy loss in male fetuses
- Autosomal dominant conditions, such as certain lethal skeletal dysplasias, which can also increase the risk of spontaneous abortion in male infants
- Genetic mutations affecting placental development or function, which can disproportionately impact male pregnancies 1
It is essential to note that male fetuses appear to be more vulnerable to adverse intrauterine conditions, showing higher sensitivity to maternal stress, infections, and environmental toxins, which can contribute to the increased risk of spontaneous abortion in male infants with non-X-linked genetic disorders 1.
From the Research
Non-X Linked Genetic Disorders and Spontaneous Abortion in Male Infants
- There are no direct research papers provided that specifically identify non-X linked genetic disorders causing spontaneous abortion in male infants 2, 3, 4.
- However, it is known that genetic problems can contribute to recurrent spontaneous abortion, and X-linked recessive disorders can result in the loss of male pregnancies 2.
- Advanced paternal age has been associated with an increased risk of spontaneous miscarriage, which may be related to genetic and epigenetic sperm abnormalities 3.
- Inheritance patterns, including autosomal dominant, autosomal recessive, and multifactorial inheritance, can contribute to the risk of genetic disorders and potentially spontaneous abortion 4.
- Further research is needed to identify specific non-X linked genetic disorders that may increase the risk of spontaneous abortion in male infants.