What are the criteria for exchange transfusion in newborns with hyperbilirubinemia?

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From the Guidelines

Exchange transfusion in newborns with hyperbilirubinemia is recommended when the total serum bilirubin (TSB) level reaches specific thresholds, such as 25-30 mg/dL (428-513 mmol/L), despite intensive phototherapy, or when there are signs of acute bilirubin encephalopathy, as indicated in the guidelines for exchange transfusion in infants 35 or more weeks’ gestation 1. The criteria for exchange transfusion vary based on gestational age and risk factors, with lower thresholds for premature infants, those with hemolytic disease, or those with risk factors such as sepsis, acidosis, or hypoalbuminemia.

  • For infants 38 0/7 weeks of gestation, exchange transfusion should be considered when the TSB level is above 25-30 mg/dL (428-513 mmol/L) or when the bilirubin/albumin (B/A) ratio exceeds 8.0, as suggested by the guidelines 1.
  • For infants 35 0/7–36 6/7 weeks of gestation and well, or 38 0/7 weeks if higher risk or isoimmune hemolytic disease or G6PD deficiency, exchange transfusion should be considered when the TSB level is above 25-30 mg/dL (428-513 mmol/L) or when the B/A ratio exceeds 7.2, as indicated in the guidelines 1.
  • For infants 35 0/7–37 6/7 weeks of gestation if higher risk or isoimmune hemolytic disease or G6PD deficiency, exchange transfusion should be considered when the TSB level is above 25-30 mg/dL (428-513 mmol/L) or when the B/A ratio exceeds 6.8, as suggested by the guidelines 1. The procedure involves removing small aliquots of the infant's blood and replacing it with donor blood, continuing until approximately twice the infant's blood volume has been exchanged, which removes about 50% of the circulating bilirubin and provides fresh albumin for binding remaining bilirubin, as described in the management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation 1.

From the Research

Criteria for Exchange Transfusion

The criteria for exchange transfusion in newborns with hyperbilirubinemia are based on several factors, including:

  • The level of bilirubin in the blood [ 2 ]
  • The presence of risk factors for bilirubin-related neurotoxicity, such as prematurity or hemolytic diseases [ 3 ]
  • The gestational age of the newborn [ 3 ]
  • The presence of neurotoxicity risk factors, such as hemolytic diseases [ 3 ]

Bilirubin/Albumin Ratio

The bilirubin/albumin ratio has been proposed as a reliable indicator of bilirubin-albumin binding and can be used to eliminate potential ambiguity in exchange transfusion criteria [ 2 ]

  • The bilirubin/albumin ratio can be used to determine the risk of bilirubin-related neurotoxicity [ 2 ]
  • The frequency curves for each unbound bilirubin concentration plotted against the bilirubin/albumin ratio were tested for normality [ 2 ]

Guidelines for Exchange Transfusion

The American Academy of Pediatrics (AAP) has released guidelines for the management of neonatal hyperbilirubinemia, including the use of exchange transfusion [ 3 ]

  • The AAP recommends universal neonatal hyperbilirubinemia screening in newborns 35 weeks' gestational age or greater [ 3 ]
  • The AAP also recommends the use of phototherapy to reduce the need for exchange transfusion [ 3 ]

Management of Jaundice

The management of jaundice in newborns depends on the underlying cause and the level of bilirubin in the blood [ 4 ]

  • Phototherapy is a simple and effective way to reduce the bilirubin level [ 4 ]
  • Exchange transfusion may be necessary in cases of severe hyperbilirubinemia or kernicterus [ 5 ]

Alloimmune Hemolytic Disease

Alloimmune hemolytic disease is a condition that occurs when fetal and neonatal erythroid cells are destroyed by maternal erythrocyte alloantibodies [ 6 ]

  • The management of alloimmune hemolytic disease includes intensive phototherapy and exchange transfusions to treat severe hyperbilirubinemia [ 6 ]
  • Top-up transfusions may be necessary to treat early and late anemia [ 6 ]

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Neonatal Hyperbilirubinemia: Evaluation and Treatment.

American family physician, 2023

Research

Neonatal jaundice: aetiology, diagnosis and treatment.

British journal of hospital medicine (London, England : 2005), 2017

Research

Single versus double volume exchange transfusion in jaundiced newborn infants.

The Cochrane database of systematic reviews, 2006

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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