From the FDA Drug Label
Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails. Urea gently dissolves the intracellular matrix which results in loosening of the horny layer of the skin and shedding of scaly skin at regular intervals, thereby softening hyperkeratotic areas of the skin.
Treatment options for keratosis pilaris include the use of urea (TOP), which can help soften hyperkeratotic areas of the skin and promote shedding of scaly skin. The key benefits of using urea for keratosis pilaris treatment are:
- Softening of hyperkeratotic areas
- Loosening of the horny layer of the skin
- Shedding of scaly skin at regular intervals 1 1
From the Research
Keratosis pilaris can be effectively treated with a 20% urea cream, as evidenced by a recent study published in 2024 2, which showed significant improvement in skin smoothness and texture after 4 weeks of use. The treatment options for keratosis pilaris are varied and depend on the severity of the condition.
- For mild cases, regular exfoliation with gentle scrubs or washcloths can help remove dead skin cells that cause the bumps.
- Moisturizing is crucial, and applying thick, fragrance-free moisturizers like CeraVe, Eucerin, or AmLactin daily after showering when skin is still damp can help.
- Products containing alpha hydroxy acids (like glycolic acid or lactic acid) or urea can help dissolve keratin buildup, with a concentration of 20% urea being particularly effective 2.
- Topical retinoids, such as tretinoin 0.025-0.05% cream, can be used for more stubborn cases, although they may cause initial irritation.
- Prescription options include stronger retinoids or short courses of topical steroids for inflammation. Some key points to consider when treating keratosis pilaris include:
- Avoiding hot showers, harsh soaps, and tight clothing that can worsen symptoms.
- Using humidifiers to help in dry environments.
- Being patient, as improvement typically takes 4-6 weeks of consistent use. It's also important to note that keratosis pilaris often improves with age, but these treatments can significantly reduce its appearance. A recent study published in 2023 3 provides an updated review on the pathogenesis, clinical manifestations, and management of keratosis pilaris, highlighting the importance of general cutaneous measures, such as hydrating skin and avoiding long baths or showers. Another study published in 2023 4 found that topical lactic acid is the most used first-line therapy for keratosis pilaris, followed by salicylic acid, and that laser therapy is only utilized by a small percentage of dermatologists due to limited insurance coverage and equipment. Overall, the most effective treatment for keratosis pilaris will depend on the individual case and may involve a combination of these options.