From the Research
Quetiapine (Seroquel) is not typically associated with causing hyperkalemia or significantly increasing potassium levels. While some antipsychotic medications can affect electrolyte balance, quetiapine is not known to directly raise potassium levels as a common side effect. Hyperkalemia (high potassium) is more commonly associated with certain medications like ACE inhibitors, ARBs, potassium-sparing diuretics, and some NSAIDs, as discussed in studies such as 1 and 2. If a patient taking quetiapine develops hyperkalemia, other causes should be investigated, such as:
- Kidney dysfunction
- Adrenal disorders
- Excessive potassium intake
- Drug interactions Patients with risk factors for electrolyte disturbances (kidney disease, heart failure, diabetes) who are prescribed quetiapine should have their electrolytes monitored periodically as a precaution, as suggested by the findings in 3. If hyperkalemia occurs while taking quetiapine, it's essential to consult a healthcare provider promptly, as untreated high potassium can lead to serious cardiac complications. The most recent and highest quality study, 3, highlights the importance of monitoring potassium levels in patients taking certain medications, but it does not indicate quetiapine as a common cause of hyperkalemia. Therefore, quetiapine is not typically associated with causing hyperkalemia, and other potential causes should be explored if hyperkalemia occurs in patients taking this medication.