Enverm is an Anthelmintic (Anti-Parasitic) Medication
Enverm (mebendazole) is a prescription anthelmintic medication used to treat intestinal worm infections caused by pinworm, whipworm, roundworm, and hookworm in adults and children 2 years of age and older. 1
Drug Classification and Mechanism
Enverm belongs to the benzimidazole class of anthelmintic agents. The active ingredient, mebendazole, works by interfering with cellular tubulin formation in helminths (parasitic worms), causing ultrastructural degenerative changes in the parasite's intestine. This disrupts glucose uptake and digestive/reproductive functions, leading to immobilization, inhibition of egg production, and ultimately death of the worm. 1
Specific Parasitic Coverage
Enverm is active against the following intestinal parasites:
- Enterobius vermicularis (pinworm)
- Trichuris trichiura (whipworm)
- Ascaris lumbricoides (roundworm)
- Ancylostoma duodenale (hookworm)
- Necator americanus (hookworm) 1
Clinical Efficacy
The medication demonstrates high cure rates across different parasitic infections:
- Pinworm: 95% mean cure rate
- Roundworm: 98% mean cure rate with 99% egg reduction
- Hookworm: 96% mean cure rate with 99% egg reduction
- Whipworm: 68% mean cure rate with 93% egg reduction 1
Formulation and Administration
Enverm is available as 100 mg chewable tablets that can be chewed, swallowed whole, or crushed and mixed with food. It can be taken with or without food. 1
Important Safety Considerations
- Contraindicated with metronidazole due to risk of severe skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) 1
- Can cause neutropenia (low white blood cell count), requiring blood count monitoring during treatment 1
- Not recommended during pregnancy or breastfeeding due to insufficient safety data 1
- Should not be used in children under 2 years of age 1