Is there a connection between cellulite and Hypermobile Ehlers-Danlos Syndrome (hEDS)?

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Last updated: June 14, 2025View editorial policy

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From the Research

There is a potential connection between cellulite and Hypermobile Ehlers-Danlos Syndrome (hEDS), though research specifically linking these conditions is limited. Cellulite may be more prevalent or pronounced in individuals with hEDS due to the underlying connective tissue abnormalities that characterize the syndrome, as noted in a study on the effects of genetic testing in hEDS diagnosis 1. hEDS involves genetic mutations affecting collagen production and connective tissue structure, resulting in joint hypermobility, skin hyperextensibility, and tissue fragility, which can be managed with approaches such as compression garments and physiotherapy, as shown in a study on the effects of compression garments on balance in hEDS patients 2. Since cellulite forms when fat deposits push through weakened connective tissue under the skin, the inherently compromised connective tissue in hEDS patients may make them more susceptible to cellulite development or more severe presentations. Additionally, the skin hyperextensibility and tissue laxity common in hEDS could potentially exacerbate the appearance of cellulite, as discussed in a report on skin fragility and wound management in Ehlers-Danlos syndromes 3. However, cellulite is extremely common in the general population (affecting 80-90% of women), so its presence alone is not diagnostic of hEDS. Management approaches for both conditions focus on maintaining healthy weight, regular exercise (particularly strength training), proper hydration, and in some cases, specialized physical therapy to improve tissue support and function, as well as techniques such as mechanical massage, manual lymphatic drainage, and connective tissue manipulation, which have been shown to be effective in reducing fat mass and regional fat thickness in women with cellulite 4. Some key points to consider in managing cellulite in hEDS patients include:

  • Maintaining a healthy weight through a balanced diet and regular exercise
  • Engaging in strength training exercises to improve tissue support and function
  • Practicing proper hydration to maintain skin health
  • Considering specialized physical therapy or techniques such as mechanical massage, manual lymphatic drainage, and connective tissue manipulation to improve tissue support and function.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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