What should I do if I've been taking expired Ativan (lorazepam) for my anxiety symptoms?

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Last updated: June 15, 2025View editorial policy

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From the Guidelines

You should stop using the expired Ativan (lorazepam) and consult your healthcare provider immediately for a proper evaluation and a new prescription. When managing anxiety symptoms, it's crucial to use medications that are within their expiration dates to ensure efficacy and safety. According to the most recent guidelines, lorazepam is recommended for anxiety or agitation at specific doses, such as 0.5-1 mg orally four times a day as required, with a maximum of 4 mg in 24 hours 1. Key considerations include:

  • The potential loss of potency in expired medications, which could reduce their effectiveness in managing anxiety symptoms.
  • The importance of medical supervision when adjusting any medication regimen, especially for benzodiazepines like Ativan, to avoid withdrawal symptoms.
  • The need for a healthcare provider to assess current symptoms and determine the best course of treatment, which may include a new prescription for Ativan at the appropriate dosage or alternative treatments. In the context of real-life clinical medicine, prioritizing morbidity, mortality, and quality of life outcomes means ensuring that patients receive effective and safe treatments for their conditions, which in this case involves not using expired medications and seeking medical advice for proper management of anxiety symptoms.

From the Research

Expired Ativan (Lorazepam) Usage

  • There is no direct evidence in the provided studies regarding the effects of taking expired Ativan (lorazepam) for anxiety symptoms.
  • However, it is known that benzodiazepines like lorazepam can be used for short-term treatment of anxiety disorders, such as panic disorder, when patients do not have a history of dependency and tolerance 2.
  • The efficacy and safety of expired medications, including lorazepam, are not addressed in the provided studies.
  • It is essential to consult a healthcare professional for proper evaluation and guidance on medication usage, especially when it comes to expired or potentially ineffective medications.

General Guidance on Anxiety Treatment

  • Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors are standard treatments for panic disorder 2, 3.
  • Benzodiazepines, such as alprazolam, can be used for short-term treatment, but they carry the risk of physical dependency 2, 3.
  • Combining drug treatment with cognitive-behavioral therapy is a successful treatment strategy for panic disorder 2, 4.
  • In cases of treatment-resistant panic disorder, alternative medications or combination treatments may be considered 4.

Safety Considerations

  • There is a risk of adverse reactions, such as serotonin syndrome, when using certain medications, including SSRIs and benzodiazepines 5, 6.
  • It is crucial to monitor patients for potential side effects and interact with healthcare professionals to ensure safe treatment.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pharmacological treatment of panic disorder.

Modern trends in pharmacopsychiatry, 2013

Research

The use of newer antidepressants for panic disorder.

The Journal of clinical psychiatry, 1997

Research

Treatment-resistant panic disorder.

CNS spectrums, 2004

Research

Serotonin syndrome from sertraline monotherapy.

The American journal of emergency medicine, 2020

Research

Fatal intoxication with a selective serotonin reuptake inhibitor, lorazepam, and codeine.

The American journal of forensic medicine and pathology, 2007

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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