Anemia of Chronic Disease (ACD): This condition is characterized by low iron levels, low Total Iron-Binding Capacity (TIBC), and elevated ferritin. The body's inflammatory response leads to increased hepcidin production, which causes iron sequestration and reduced iron availability for erythropoiesis, despite adequate iron stores.

Chronic Inflammation: Conditions such as rheumatoid arthritis, chronic infections, or other inflammatory diseases can lead to similar laboratory findings due to the body's acute phase response, which increases ferritin and decreases TIBC.
Obesity: Obesity is associated with chronic inflammation, which can result in elevated ferritin levels and low TIBC, even in the absence of other obvious inflammatory conditions.
Nephrotic Syndrome: This condition can lead to hypoalbuminemia, which in turn can cause a decrease in TIBC. Additionally, inflammation and oxidative stress associated with nephrotic syndrome may elevate ferritin levels.

Hemochromatosis: Although less likely given the low iron and low TIBC, it's crucial not to miss this diagnosis. Early stages or specific variants of hemochromatosis might present with these lab findings, especially if phlebotomy has been recently performed.
Malignancy: Certain cancers can cause an inflammatory response leading to elevated ferritin and altered iron studies. It's essential to consider malignancy, especially in patients with unexplained weight loss, night sweats, or other systemic symptoms.

Hemophagocytic Lymphohistiocytosis (HLH): A rare disorder of the immune system where the body produces too many activated immune cells called macrophages and lymphocytes. These cells can infiltrate various tissues and lead to the consumption of blood cells and platelets, resulting in elevated ferritin levels.
Porphyria Cutanea Tarda: A disorder that can lead to increased iron absorption and subsequent elevation in ferritin levels. It might present with skin manifestations and, occasionally, with altered iron studies.