What are the best supplements for anxiety?

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Last updated: June 16, 2025View editorial policy

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From the Guidelines

Lavender and passionflower supplements are recommended for anxiety management, as they have shown efficacy and safety in reducing anxiety, according to the most recent and highest quality study 1. When considering supplements for anxiety, it's essential to prioritize those with the most promising evidence.

  • Lavender supplementation has been shown to be efficacious and safe in the treatment of anxiety, including preoperatively, with no clinical evidence to suggest it may potentiate anesthetic effects 1.
  • Passionflower is primarily known for its anxiolytic effects and has been studied in the perioperative setting, demonstrating a reduction in anxiety with a good safety profile 1. Other supplements, such as melatonin, may also be beneficial in reducing anxiety, as it has been found to be safe in the perioperative period and may decrease delirium in hospitalized elderly patients 1. However, it's crucial to consult with a healthcare provider before beginning any supplement regimen, especially if you take medications or have existing health conditions, to ensure safe and effective management of anxiety. Some supplements, like kratom, L-arginine, and L-tryptophan, may have potential risks or interactions and should be approached with caution or avoided altogether 1. Ultimately, the decision to use supplements for anxiety management should be made in consultation with a healthcare provider, taking into account individual needs and circumstances, and prioritizing evidence-based recommendations 1.

From the Research

Best Supplements for Anxiety

Some studies suggest that certain supplements may help alleviate anxiety symptoms. The following are some of the best supplements for anxiety:

  • Omega-3 fatty acids: Research has shown that omega-3 fatty acids, particularly EPA and DHA, may have a positive effect on anxiety symptoms 2, 3, 4, 5.
  • Inositol: Some studies have found that inositol may have a modest effect in reducing anxiety symptoms, particularly in patients with panic disorder or obsessive-compulsive disorder 6.
  • Kava: Kava has been found to have a potential benefit in reducing anxiety symptoms, particularly in patients with mild to moderate anxiety 6.

Dosage and Efficacy

The optimal dosage of omega-3 fatty acids for anxiety symptoms is still unclear. However, one study found that a dose of 2g per day may be the most effective in reducing anxiety symptoms 3. It's essential to note that while these supplements may have a potential benefit, the evidence is not yet conclusive, and more research is needed to fully understand their effects on anxiety symptoms.

Safety and Interactions

Omega-3 fatty acids are generally considered safe and well-tolerated. However, high doses may interact with certain medications, such as blood thinners 3. Inositol and kava may also interact with certain medications, and their long-term safety is not well established 6. It's crucial to consult with a healthcare professional before taking any supplements, especially if you're already taking medications or have a medical condition.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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