What other symptoms would result from C5-C6 nerve root inflammation?

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Last updated: June 16, 2025View editorial policy

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From the Research

C5-C6 nerve root inflammation typically causes several distinct symptoms, including pain radiating from the neck down the arm to the thumb and index finger, accompanied by numbness and tingling in the same distribution, as well as muscle weakness affecting the biceps, wrist extensors, and shoulder muscles. These symptoms occur because the C5-C6 nerve roots supply sensation to the lateral arm, thumb, and index finger, while also innervating key muscles in the upper limb 1. The inflammation compresses these nerve fibers, disrupting both sensory and motor functions in their specific distribution patterns.

Key Symptoms

  • Pain radiating from the neck down the arm to the thumb and index finger
  • Numbness and tingling in the same distribution
  • Muscle weakness affecting the biceps, wrist extensors, and shoulder muscles
  • Diminished biceps reflex
  • Difficulty with shoulder abduction and elbow flexion
  • Neck stiffness
  • Headaches radiating from the base of the skull
  • Hand coordination problems

Treatment Options

Treatment for C5-C6 nerve root inflammation may involve corticosteroids, which have been shown to have anti-inflammatory effects and improve symptoms in some cases 2, 3. However, the evidence for the effectiveness of corticosteroids is not strong, and more research is needed to determine the best course of treatment.

Important Considerations

It is essential to note that the symptoms of C5-C6 nerve root inflammation can vary depending on the individual and the severity of the inflammation. A thorough medical evaluation is necessary to determine the underlying cause of the symptoms and develop an effective treatment plan. Additionally, while corticosteroids may be beneficial in some cases, they can also have serious side effects, particularly with long-term use 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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