What to do for throat itchiness with oral allergy syndrome while already taking Claritin (loratadine)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 16, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

For throat itchiness from oral allergy syndrome while already taking Claritin, try adding a steroid nasal spray like fluticasone (Flonase) or triamcinolone (Nasacort), which can reduce inflammation in the throat area. You can also use throat lozenges containing benzocaine or menthol for temporary relief. Consider avoiding raw fruits and vegetables that trigger your symptoms, or try peeling or cooking them, as this often destroys the allergens 1. Drinking cold liquids or eating ice chips may provide immediate soothing relief. If Claritin isn't effective enough, discuss with your doctor about switching to a different antihistamine like cetirizine (Zyrtec) or fexofenadine (Allegra), which some people find more effective for oral allergy syndrome 1. These approaches work because oral allergy syndrome occurs when proteins in certain foods cross-react with pollen allergies, causing local inflammation.

Some key points to consider:

  • Second-generation antihistamines, such as loratadine, are generally preferred over first-generation antihistamines due to their lower risk of sedation and anticholinergic effects 1.
  • Among the second-generation antihistamines, no single agent has been conclusively found to achieve superior overall response rates 1.
  • Steroid nasal sprays, such as fluticasone or triamcinolone, can be effective in reducing inflammation and relieving symptoms of allergic rhinitis, including throat itchiness 1.
  • Avoiding triggers and using throat lozenges or cold liquids can provide temporary relief and help manage symptoms.

It's essential to consult with your healthcare provider if symptoms persist or worsen despite these measures, as you may need prescription-strength medication or further evaluation.

From the FDA Drug Label

INDICATIONS AND USAGESeasonal Allergic RhinitisFexofenadine Hydrochloride Tablets are indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Symptoms treated effectively were sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes.

The FDA drug label does not answer the question about what to do for throat itchiness with oral allergy syndrome while already taking Claritin (loratadine) 2.

From the Research

Managing Throat Itchiness with Oral Allergy Syndrome

If you are experiencing throat itchiness due to oral allergy syndrome and are already taking Claritin (loratadine), consider the following options:

  • Identify and avoid trigger foods that cause your oral allergy syndrome symptoms, as suggested by studies on oral allergy syndrome 3
  • Consider alternative antihistamines, such as fexofenadine, which have been shown to be effective in managing seasonal allergic rhinitis and chronic idiopathic urticaria 4
  • Be aware of the potential for anaphylaxis, especially if you have a history of severe reactions, as noted in a study on oral allergy syndrome and anaphylaxis risk 5

Antihistamine Options

When choosing an antihistamine, consider the following:

  • Second-generation antihistamines, such as loratadine, desloratadine, cetirizine, and fexofenadine, are generally preferred over first-generation antihistamines due to their lower risk of sedation and impairment 6
  • Fexofenadine has been shown to be effective in relieving symptoms of seasonal allergic rhinitis, including sneezing, rhinorrhoea, and itchy throat 4
  • Desloratadine, a new selective histamine H(1)-receptor antagonist, has potent antihistaminic and anti-inflammatory activity and may be effective in treating systemic aspects of allergic disease 7

Important Considerations

Keep in mind that:

  • Oral allergy syndrome can be triggered by various foods, including fruits, nuts, and vegetables, and symptoms can range from mild to severe 3
  • Patients with oral allergy syndrome should be aware of the potential for anaphylaxis and take steps to manage their symptoms and avoid trigger foods 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Oral allergy syndrome.

American journal of rhinology & allergy, 2018

Research

Can patients with oral allergy syndrome be at risk of anaphylaxis?

Current opinion in allergy and clinical immunology, 2020

Research

First do no harm: managing antihistamine impairment in patients with allergic rhinitis.

The Journal of allergy and clinical immunology, 2003

Research

Therapeutic options in allergic disease: antihistamines as systemic antiallergic agents.

The Journal of allergy and clinical immunology, 2000

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.