What supplements can be used to treat Gastroesophageal Reflux Disease (GERD)?

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Last updated: June 16, 2025View editorial policy

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From the Guidelines

The most effective supplement to treat GERD is alginate, which can be used in addition to proton pump inhibitors (PPIs) to improve control of GERD symptoms, as demonstrated in a study published in Gut 1. When considering supplements to manage Gastroesophageal Reflux Disease (GERD) symptoms, it's essential to prioritize those that have shown efficacy in improving symptoms and quality of life.

  • Alginate, in particular, has been shown to be beneficial in reducing post-reflux symptoms and improving control of GERD symptoms when used in addition to PPIs 1.
  • Other supplements like deglycyrrhizinated licorice (DGL), melatonin, ginger, probiotics, D-limonene, slippery elm powder, and chamomile tea may also be helpful in managing GERD symptoms, but their effectiveness is not as well-established as alginate.
  • It's crucial to note that lifestyle modifications, such as weight loss, bed elevation, and avoiding trigger foods, should be implemented alongside any supplement regimen to optimize symptom control, as recommended by the Asia-Pacific consensus on the management of gastro-oesophageal reflux disease 1.
  • Additionally, a personalized approach to the evaluation and management of GERD, as outlined in the AGA clinical practice update, should be considered to ensure the most effective treatment plan for each individual patient 1.

From the Research

Supplements for Treating GERD

There are several supplements that can be used to treat Gastroesophageal Reflux Disease (GERD), including:

  • Melatonin: A study published in 2011 found that melatonin may help prevent esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals, and further studies are required to establish its effectiveness in humans 2.
  • Alginate: A systematic review and meta-analysis published in 2017 found that alginate-based therapies are effective in treating GERD symptoms, particularly when compared to placebo or antacids 3.

Lifestyle Changes and Diet

In addition to supplements, lifestyle changes and dietary modifications can also play a crucial role in managing GERD symptoms, including:

  • Avoiding trigger foods such as salt, salted foods, chocolate, fatty foods, and fizzy drinks 4, 5
  • Eating a low-fat diet and avoiding lying on the left side and raising the head of the bed in a supine position to reduce nocturnal reflux symptoms 6, 4
  • Maintaining a healthy weight, as obesity can trigger GERD symptoms 4, 5
  • Engaging in regular and mild-moderate physical activity, which can help reduce reflux symptoms 4

Other Considerations

It's worth noting that while these supplements and lifestyle changes may be beneficial in managing GERD symptoms, they should not replace medical treatment. It's essential to consult with a healthcare professional for proper diagnosis and treatment of GERD. Additionally, more research is needed to fully understand the effectiveness of these supplements and lifestyle changes in treating GERD 2, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Does a melatonin supplement alter the course of gastro-esophageal reflux disease?

World journal of gastrointestinal pharmacology and therapeutics, 2011

Research

Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2017

Research

The role of lifestyle changes in gastroesophageal reflux diseases treatment.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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