From the Research
Cyclobenzaprine may be beneficial in reducing nocturnal bruxism, but its use should be carefully considered due to potential side effects and interactions. As a muscle relaxant, cyclobenzaprine works by blocking nerve impulses that cause muscle spasms, potentially reducing the jaw muscle activity involved in bruxism 1. The typical dosage when prescribed off-label for this purpose is 5-10 mg taken 30-60 minutes before bedtime.
Key Considerations
- Side effects can include drowsiness, dry mouth, and dizziness, which is why it's often prescribed at a lower dose initially 2.
- Cyclobenzaprine is generally recommended for short-term use (2-3 weeks) rather than as a long-term solution.
- The medication addresses the muscle tension component of bruxism but doesn't treat potential underlying causes like stress, sleep disorders, or dental issues.
- For comprehensive management of bruxism, cyclobenzaprine might be combined with other approaches such as a dental night guard, stress reduction techniques, and improved sleep hygiene.
Important Precautions
- Patients with heart conditions, glaucoma, urinary retention, or those taking MAO inhibitors should avoid cyclobenzaprine due to potential serious interactions 1.
- Cyclobenzaprine has been shown to be a potent non-competitive antagonist of histamine H1 receptors, which may contribute to its sedative effects 1.
- The use of cyclobenzaprine for myofascial pain has been studied, but there is insufficient evidence to support its use for this condition, and further high-quality RCTs are needed 3.
Dosage and Administration
- The typical dosage of cyclobenzaprine for nocturnal bruxism is 5-10 mg taken 30-60 minutes before bedtime.
- Cyclobenzaprine can be administered in an extended-release formulation, which may provide more consistent relief from muscle spasms throughout the night 4.