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Differential Diagnosis for Swelling on the Upper Outer Corner

  • Single most likely diagnosis
    • Preseptal or Periorbital Cellulitis: This is a common condition that can cause swelling on the upper outer corner of the eye due to an infection. The proximity of the swelling to the eye and the potential for redness and warmth make this a likely diagnosis.
  • Other Likely diagnoses
    • Hordeolum (Stye): A localized infection or inflammation of the eyelid margin involving hair follicles of the eyelashes or meibomian glands. It presents as a painful, swollen nodule on the eyelid, which could be on the upper outer corner.
    • Chalazion: A small bump on the eyelid due to a blocked oil gland. While typically painless, if it becomes inflamed, it could cause noticeable swelling.
    • Blepharitis: Inflammation of the eyelids that can cause swelling, particularly if the condition is severe or if there's an associated infection.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Orbital Cellulitis: A serious infection of the tissues surrounding the eye, which can lead to severe complications, including vision loss and cavernous sinus thrombosis. Early differentiation from preseptal cellulitis is crucial.
    • Angioedema: A condition characterized by rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues. It can be life-threatening if it involves the airway.
  • Rare diagnoses
    • Dacryocystitis: An infection of the lacrimal sac, usually presenting with pain, swelling, and redness in the area of the lacrimal sac (near the inner corner of the eye), but could potentially cause swelling that might be perceived as being on the upper outer corner if the infection spreads.
    • Sarcoidosis: A condition that can cause inflammation in various parts of the body, including the eyes. It might lead to swelling around the eyes, though this would be less common and part of a broader systemic disease presentation.
    • Lacrimal Gland Tumor: Rare tumors of the lacrimal gland can cause swelling in the outer corner of the eye. These are uncommon and usually present with more specific symptoms related to the gland's location and function.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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