From the Research
Damiana is unlikely to cause significant elevations in liver function tests (LFTs) as it has been found to have hepatoprotective effects, as evidenced by the identification of hepatodamianol, a compound with a four times greater hepatoprotective effect than silibinin against carbon tetrachloride damage in an in vitro model using HepG2 cells 1. However, it is essential to note that herbal supplements, in general, can pose a risk of liver injury, and patients with pre-existing liver conditions or those taking medications metabolized by the liver should exercise caution when using damiana. Some studies suggest that the risk of elevated LFTs is higher with prolonged use or high doses of certain herbal supplements 2, but there is limited data specifically on damiana. It is crucial to monitor liver function regularly if you choose to use damiana long-term and to inform your healthcare provider about all supplements you're taking. Additionally, if you experience symptoms like jaundice, abdominal pain, fatigue, or dark urine while taking damiana, discontinue use immediately and consult a healthcare provider. The lack of rigorous safety testing for herbal supplements, including damiana, means that their effects on liver function are not fully understood, and more research is needed to determine their potential hepatotoxicity 3. In the context of real-life clinical medicine, it is always better to err on the side of caution when it comes to potential liver injury, and patients should be advised to be aware of the potential risks associated with herbal supplement use. Key points to consider include:
- Damiana has been found to have hepatoprotective effects
- Herbal supplements can pose a risk of liver injury
- Patients with pre-existing liver conditions or those taking medications metabolized by the liver should exercise caution
- Regular monitoring of liver function is advisable with long-term use
- Inform your healthcare provider about all supplements you're taking
- Discontinue use and consult a healthcare provider if you experience symptoms of liver injury.