From the Guidelines
Yes, NPH (Neutral Protamine Hagedorn) insulin is administered subcutaneously (subQ). According to the most recent and highest quality study, NPH insulin should be administered subcutaneously to cover basal insulin needs in patients receiving enteral or parenteral feedings 1. The study recommends using NPH insulin twice or three times daily to cover patient needs, with adjustments made frequently. Additionally, correctional insulin should also be administered subcutaneously every 6 h using human regular insulin or every 4 h using a rapid-acting insulin.
- Key points to consider when administering NPH insulin subcutaneously include:
- Rotating injection sites within the same general area to prevent lipohypertrophy or lipoatrophy
- Using a standard administration technique, such as pinching a fold of skin and injecting at a 90-degree angle with a short needle
- Gentle rolling of the vial between the palms to ensure proper mixing before administration
- Gradual absorption of insulin into the bloodstream, providing consistent blood glucose control
- It is essential to note that the administration of NPH insulin subcutaneously is a common practice, and the most recent study 1 supports this approach, whereas the previous study 1 also recommends subcutaneous administration, but the most recent one takes precedence.
From the Research
Administration of NPH Insulin
- NPH (Neutral Protamine Hagedorn) insulin is administered subcutaneously (subQ) 2, 3, 4.
- The absorption rate of NPH insulin can vary depending on the injection site, with the thigh being a preferred site for subcutaneous injection 3.
- Studies have compared the absorption of NPH insulin when injected subcutaneously in the abdominal wall and thigh, with results showing similar absorption rates 2, 3.
- NPH insulin has also been compared to other types of insulin, such as lente insulin, in terms of metabolic control, with results showing equivalent control 5.
- The administration of NPH insulin subcutaneously has been studied in various patient populations, including diabetic patients undergoing surgery, with results showing effective diabetic control 6.