From the Research
Mirabegron can generally be used in patients with photosensitivity concerns as it is not known to cause significant photosensitivity reactions. This medication, commonly prescribed under brand names like Myrbetriq for overactive bladder, works by activating beta-3 adrenergic receptors in the bladder to improve storage capacity without the anticholinergic side effects of traditional overactive bladder medications. Unlike some medications that can increase skin sensitivity to sunlight (such as tetracycline antibiotics, certain diuretics, or some antipsychotics), mirabegron has not been associated with photosensitivity in clinical trials or post-marketing surveillance 1.
The typical dosing for mirabegron is 25-50 mg once daily, with 25 mg being the recommended starting dose for patients with renal or hepatic impairment. While patients can take this medication without specific sun protection precautions related to the drug itself, standard sun protection measures are always advisable for general skin health. If a patient with a history of severe photosensitivity reactions is concerned, they should monitor for any unusual skin reactions when starting the medication, though such reactions would be unexpected with mirabegron.
Some key points to consider when prescribing mirabegron include:
- Its efficacy in treating overactive bladder symptoms, including micturition frequency, urgency incontinence, and urgency 2
- Its favorable safety and tolerability profile, particularly compared with antimuscarinics, for dry mouth, constipation, and many CNS effects 1
- The importance of monitoring for any unusual skin reactions, although photosensitivity is not a known side effect of mirabegron 3
Overall, mirabegron is a viable treatment option for patients with overactive bladder, including those with concerns about photosensitivity, due to its efficacy and safety profile.