From the Research
The recommended dosage of Inj Botropase is typically 1-2 units administered intramuscularly or intravenously, depending on the severity of the bleeding condition being treated. For most surgical procedures, a single dose of 1 unit given 15-30 minutes before surgery is sufficient, while for more extensive bleeding, 2 units may be administered. For ongoing bleeding, the dose can be repeated every 4-6 hours as needed, but should not exceed 4 units in 24 hours. It's essential to note that Botropase and botulinum toxin (Botox) are entirely different medications - Botropase helps control bleeding by promoting blood clotting, while botulinum toxin relaxes muscles and is used for different medical purposes. Before administration, the patient should be tested for hypersensitivity, and the medication should be used cautiously in patients with liver disease, pregnancy, or those on anticoagulant therapy. The medication works by converting fibrinogen to fibrin, thereby accelerating blood clot formation at bleeding sites.
Some studies have investigated the use of thrombolytic agents in acute ischemic stroke, such as the use of alteplase 1 and streptokinase 2, but these are not directly related to the dosage of Inj Botropase. Other studies have examined the safety of intra-arterial treatment in acute ischemic stroke patients on oral anticoagulants 3 and the optimal dose of intravenous tissue-type plasminogen activator for stroke 4, but these are also not relevant to the dosage of Inj Botropase.
Key points to consider when administering Inj Botropase include:
- The dosage should be individualized based on the severity of the bleeding condition
- The medication should be used cautiously in patients with certain medical conditions, such as liver disease or pregnancy
- The patient should be tested for hypersensitivity before administration
- The medication should not be used in patients with a history of hypersensitivity to batroxobin or other components of the medication.
Overall, the recommended dosage of Inj Botropase is 1-2 units administered intramuscularly or intravenously, depending on the severity of the bleeding condition being treated, and the medication should be used with caution in certain patient populations.