From the FDA Drug Label
Use of NSAIDs, including diclofenac sodium topical solution, can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment Because of these risks, limit dose and duration of diclofenac sodium topical solution use between about 20 and 30 weeks of gestation, and avoid diclofenac sodium topical solution use at about 30 weeks of gestation and later in pregnancy Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy, because NSAIDs, including diclofenac sodium topical solution, can cause premature closure of the fetal ductus arteriosus
No, Coltrane (diclofenac) gel should not be used at 32 weeks of pregnancy, as it may cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction, according to the FDA drug label 1.
From the Research
Diclofenac gel (Coltrane) is not recommended for use at 32 weeks of pregnancy. All NSAIDs, including topical diclofenac, should be avoided during the third trimester of pregnancy (beyond 28 weeks) due to potential risks to the developing fetus, as noted in a study published in 2012 2. Even though topical applications have lower systemic absorption than oral forms, there is still potential risk to the fetus. NSAIDs at this stage of pregnancy can cause premature closure of the ductus arteriosus in the baby's heart, potentially leading to pulmonary hypertension. They may also affect the baby's kidney function, reduce amniotic fluid levels, and potentially prolong labor and increase bleeding during delivery.
The use of NSAIDs during pregnancy, especially in the third trimester, is a concern due to the potential for adverse effects on the fetus, as discussed in a study from 2012 2. The study highlights the importance of considering the risks and benefits of NSAID use during pregnancy and using the lowest effective dose for the shortest duration possible.
If you need pain relief during the third trimester, acetaminophen (Tylenol) is generally considered safer for pregnancy, but you should always consult with your healthcare provider before taking any medication during pregnancy, as advised in a 2021 article 3. They can recommend appropriate alternatives based on your specific medical situation and pain management needs. It's essential to prioritize the safety of both the mother and the fetus when considering medication use during pregnancy.
Key points to consider:
- Avoid NSAIDs, including topical diclofenac, in the third trimester of pregnancy
- Use acetaminophen (Tylenol) as a safer alternative for pain relief during pregnancy, under healthcare provider guidance
- Consult with a healthcare provider before taking any medication during pregnancy to discuss potential risks and benefits
- Prioritize the safety of both the mother and the fetus when considering medication use during pregnancy, as emphasized in studies such as 2 and 3.