What is the recommended Augmentin (amoxicillin-clavulanate) treatment regimen for diverticulitis?

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Last updated: June 18, 2025View editorial policy

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From the Research

The recommended Augmentin (amoxicillin-clavulanate) treatment regimen for diverticulitis is typically 875 mg/125 mg taken orally twice daily for 5-7 days, as supported by the most recent study 1. This dosage provides sufficient antimicrobial coverage against the common bacteria involved in diverticulitis, including gram-negative rods and anaerobes found in the colon. Some key points to consider when treating diverticulitis with Augmentin include:

  • Patients should take Augmentin with food to minimize gastrointestinal side effects such as nausea or diarrhea.
  • It's essential to complete the entire course of antibiotics even if symptoms improve before finishing the prescription.
  • For patients with penicillin allergy, alternative regimens would be necessary.
  • Adequate hydration and a temporary liquid or low-residue diet during the acute phase can help manage symptoms while the antibiotics work to resolve the infection.
  • This regimen is typically part of outpatient management for uncomplicated diverticulitis, while complicated cases may require intravenous antibiotics and possibly surgical intervention. The most recent study 1 demonstrates that a shorter course of Augmentin treatment (5 days) can be equally effective and more efficient in managing uncomplicated acute diverticulitis, with a significant reduction in health costs.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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