From the FDA Drug Label
Dosage and Administration: Usual adult dose is 2 dropperfuls or 2 mL daily. For the best results, the product should be taken daily. Description: Pure Vita Vitamin D3 (Cholecalciferol) and Vitamin K2 (Menatetrenone-MK4) work together to support bone helath, calcium absorption and heart health.
The recommended dosage of vitamin K2 is 2 dropperfuls or 2 mL daily 1. Vitamin K2, specifically Menatetrenone-MK4, works together with vitamin D3 to support bone health, calcium absorption, and heart health 1.
- The product should be taken daily for the best results.
- Vitamin K2 helps maintain strong bones, immune function, and proper calcium distribution for overall well-being 1.
From the Research
Vitamin K2 supplementation is recommended for patients with osteoporosis or cardiovascular disease, with a typical dosage of 100-200 mcg daily, and MK-7 being the preferred form due to its longer half-life and better bioavailability. The most recent study on this topic, published in 2020 2, suggests that vitamin K2 supplementation may improve bone quality and reduce fracture risk in osteoporotic patients. Another study from 2020 3 also supports the use of vitamin K2 in the treatment of bone loss, as it contributes to the structural integrity of osteocalcin, the major non-collagenous protein found in bone matrix.
Key points to consider when recommending vitamin K2 supplementation include:
- The importance of taking the supplement with a meal containing some fat to enhance absorption
- The potential for vitamin K2 to work synergistically with calcium and vitamin D supplements to improve bone health
- The need for patients on warfarin to avoid vitamin K2 supplements due to potential interference with anticoagulation
- The availability of K2 supplements in MK-4 or MK-7 forms, with MK-7 generally preferred for its longer-lasting effects and once-daily dosing convenience
It is also important to note that while the evidence suggests that vitamin K2 supplementation may be beneficial for patients with osteoporosis or cardiovascular disease, the data is not yet conclusive, and more research is needed to fully understand the effects of vitamin K2 supplementation on skeletal health 2. However, based on the current evidence, vitamin K2 supplementation is a promising adjunctive therapy for the prevention and treatment of osteoporosis and cardiovascular disease.