From the FDA Drug Label
DOSAGE AND ADMINISTRATION Prevention of Endometrial Hyperplasia Progesterone capsules should be given as a single daily dose at bedtime, 200 mg orally for 12 days sequentially per 28-day cycle, to a postmenopausal woman with a uterus who is receiving daily conjugated estrogens tablets. Treatment of Secondary Amenorrhea Progesterone capsules may be given as a single daily dose of 400 mg at bedtime for 10 days.
The typical dosage for Prometrium (progesterone) is 200 mg orally for 12 days sequentially per 28-day cycle for the prevention of endometrial hyperplasia, and 400 mg at bedtime for 10 days for the treatment of secondary amenorrhea. The provided dosage of 100mg is not explicitly mentioned in the provided drug label for the standard treatment plans. 1
From the Research
Prometrium (progesterone) 100mg is typically prescribed at a dosage that varies based on the individual's condition and treatment goals, but a common dosage is 200mg daily, taken orally at bedtime, for hormone replacement therapy or to address progesterone deficiency. For menopause symptoms, it's usually combined with estrogen therapy and taken for 12-14 days per month in sequential regimens, or daily in continuous regimens. For luteal phase support in fertility treatments, dosages range from 100-200mg two to three times daily, as supported by recent studies such as 2, which highlights the importance of individualizing luteal phase support according to the needs of each patient. For endometrial hyperplasia prevention, 200mg daily for 12-14 days per month is common. The medication should be taken with food to enhance absorption, and at night because it may cause drowsiness. Prometrium is a bioidentical form of progesterone that helps balance estrogen effects, protecting the endometrium from overgrowth while supporting pregnancy maintenance in fertility treatments. Side effects may include dizziness, headaches, breast tenderness, and mood changes. Patients should follow their healthcare provider's specific instructions as dosing varies based on individual conditions and treatment goals.
Some key points to consider when prescribing Prometrium include:
- The importance of individualizing treatment based on the patient's specific needs and condition, as emphasized in 2
- The need to monitor for potential side effects and adjust the dosage accordingly
- The importance of taking the medication with food and at night to enhance absorption and minimize drowsiness
- The potential for Prometrium to interact with other medications, and the need to carefully consider these interactions when prescribing the medication
It's also important to note that the evidence for Prometrium's use in various conditions is based on studies such as 3, which demonstrated the efficacy of oral micronized progesterone in inducing withdrawal bleeding in women with secondary amenorrhea. However, the most recent and highest quality study, 2, provides the most up-to-date guidance on the use of progesterone in assisted reproductive technology, and should be prioritized when making treatment decisions.