Can lanreotide (somatostatin analogue) cause neuropathy?

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Last updated: June 21, 2025View editorial policy

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From the Research

Lanreotide, a somatostatin analogue, is not commonly associated with causing neuropathy, and there is limited evidence to suggest a direct link between lanreotide and neuropathy in patients with neuroendocrine tumors or other conditions. The available studies, such as the one published in the Journal of gastrointestinal oncology 1, do not mention neuropathy as a common side effect of lanreotide treatment. However, it is essential to note that somatostatin analogues, in general, can have various side effects, and neurological symptoms, including neuropathy, have been reported in some cases, although this is not specific to lanreotide and may be more related to the underlying disease or other treatments. Patients taking lanreotide should be monitored for any neurological symptoms, and if such symptoms occur, they should be reported to the healthcare provider for appropriate management. The mechanism behind potential neuropathy, if it were to occur, could relate to effects on nerve function or growth factor signaling, but this is speculative and not directly supported by the provided evidence. Given the lack of direct evidence linking lanreotide to neuropathy, the primary concern should be the management of the underlying condition for which lanreotide is prescribed, with monitoring for any potential side effects, including neurological symptoms. Healthcare providers should be aware of the potential, albeit uncommon, for neuropathy or other neurological side effects in patients on lanreotide, based on the general principles of somatostatin analogue therapy, as discussed in studies like those found in the Journal of gastrointestinal oncology 1 and other publications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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