From the Research
Muscle twitching is a possible side effect of citicoline (CDP-choline) at higher doses like 3000mg daily, though it's not among the most commonly reported adverse effects. The chances of experiencing muscle twitching with this dose are relatively low, occurring in less than 5% of users according to available clinical data 1. More common side effects at this dose include headaches, digestive issues (nausea, diarrhea), and insomnia. The 3000mg dose is at the upper end of typical therapeutic ranges, which may increase the likelihood of side effects compared to lower doses (500-2000mg daily). Muscle twitching from citicoline is typically mild and transient, often resolving as your body adjusts to the supplement. If you experience persistent or severe muscle twitching while taking citicoline, you should reduce the dose or discontinue use and consult a healthcare provider. These effects likely occur because citicoline increases acetylcholine levels in the nervous system, which can temporarily affect neuromuscular signaling and lead to involuntary muscle contractions in some individuals. It's worth noting that the most recent and highest quality study on citicoline, which was published in 2013 2, did not specifically report muscle twitching as a side effect, but it did show that long-term treatment with citicoline may improve poststroke vascular cognitive impairment, suggesting that citicoline is generally safe and well-tolerated. However, the study that most directly addresses the safety profile of citicoline, including potential side effects like muscle twitching, is the 2006 review 1, which emphasizes the safety and tolerability of citicoline across various doses and patient populations. Given the available evidence, the risk of muscle twitching with 3000mg of citicoline daily is considered low, and most individuals can expect to tolerate this dose without significant side effects.