From the Research
Yes, a person taking 500mg of vitamin B6 (pyridoxine) for the first time has a significantly higher risk of developing muscle twitching, with an estimated risk of approximately 40-50%. This dose is far above the recommended daily allowance of 1.3-1.7mg for adults and exceeds the tolerable upper intake level of 100mg per day, as noted in studies such as 1 and 2. Muscle twitching occurs because excessive vitamin B6 can be neurotoxic, causing peripheral neuropathy where nerves that control muscles become damaged. Other symptoms may include numbness, tingling sensations, and reduced sensation to touch, temperature, or vibration. These symptoms typically develop after prolonged use but can appear within weeks at such high doses.
The most recent and highest quality study, 2, published in 2023, supports the notion that high levels of vitamin B6 can lead to peripheral neuropathy, which is consistent with the development of muscle twitching and other neurological symptoms. This study emphasizes the importance of caution when taking high doses of vitamin B6, especially for individuals who have never taken it before.
Key points to consider:
- The recommended daily intake of vitamin B6 is significantly lower than 500mg, as indicated by 3 and 4.
- High doses of vitamin B6 can cause neurotoxicity, leading to symptoms such as muscle twitching, numbness, and tingling sensations, as reported in 1 and 2.
- The risk of developing these symptoms is higher when taking doses above the tolerable upper intake level, which is 100mg per day, as stated in 1.
- If muscle twitching or other neurological symptoms occur, it is essential to discontinue use of high-dose vitamin B6 and consult a healthcare provider, as the symptoms can improve after stopping the supplement, though recovery may take time, depending on the severity and duration of exposure, as suggested by 2.