From the Research
Ashwagandha may interact with Lexapro (escitalopram), and combining these substances is generally not recommended without medical supervision. Both ashwagandha and Lexapro can increase serotonin levels in the brain, which creates a potential risk for serotonin syndrome, a serious condition characterized by symptoms like confusion, rapid heart rate, high blood pressure, dilated pupils, muscle rigidity, and in severe cases, seizures or loss of consciousness 1. Additionally, ashwagandha has mild sedative properties that could potentially enhance the side effects of Lexapro such as drowsiness or dizziness.
Some key points to consider:
- A study published in the Journal of integrative and complementary medicine found that ashwagandha root extract increased serotonin levels in individuals with mild to moderate depression and anxiety 1.
- Another study published in Phytotherapy research found that ashwagandha supplementation significantly reduced anxiety and stress levels compared to a placebo 2.
- However, it's essential to note that the certainty of the evidence was low for both outcomes, and further high-quality studies are needed to firmly establish the clinical efficacy of ashwagandha 2.
If you're currently taking Lexapro and are interested in using ashwagandha, it's essential to consult with your healthcare provider first. They can evaluate your specific situation, including your current dosage of Lexapro (typically 10-20mg daily), other medications you may be taking, and your overall health status to determine if this combination would be safe for you. Never start or stop either substance without professional guidance, as abrupt changes can lead to withdrawal symptoms or worsening of the condition being treated.