From the FDA Drug Label
Pregabalin treatment may cause weight gain. In pregabalin controlled clinical trials in adult patients of up to 14 weeks, a gain of 7% or more over baseline weight was observed in 9% of pregabalin-treated patients and 2% of placebo-treated patients. Weight gain was reported in 0% (0/60) of patients on thiazolidiones only; 4% (35/859) of patients on pregabalin only; and 7. 5% (9/120) of patients on both drugs. Among diabetic patients, pregabalin-treated patients gained an average of 1.6 kg (range: -16 to 16 kg), compared to an average 0. 3 kg (range: -10 to 9 kg) weight gain in placebo patients. In a cohort of 333 diabetic patients who received pregabalin for at least 2 years, the average weight gain was 5. 2 kg.
Yes, Lyrica (pregabalin) may cause weight gain. The incidence of weight gain was higher in patients taking pregabalin compared to those taking a placebo, with 9% of pregabalin-treated patients experiencing a gain of 7% or more over baseline weight 1.
From the Research
Yes, Lyrica (pregabalin) can cause weight gain in many patients. According to the most recent study from 2022 2, pregabalin is one of the most common drugs associated with weight gain, with 3.86% of reports submitted to the US FDA Adverse Event Reporting System (FAERS) related to weight gain. Clinical studies show that approximately 5-16% of people taking Lyrica experience weight gain as a side effect, with higher doses generally associated with more significant weight changes. The average weight gain is about 2-9 pounds, though some patients may gain more. This weight gain typically occurs gradually over the first 6 months of treatment. The mechanism behind this side effect involves pregabalin's effects on appetite regulation in the brain and potential fluid retention.
Some key points to consider:
- Pregabalin has been approved for the treatment of generalized anxiety disorder (GAD) in adults, and its use has been associated with weight gain as a side effect 3.
- The risk of weight gain with pregabalin is significant, and healthcare providers should educate their patients about the potential for weight gain when taking this medication 2.
- Maintaining a balanced diet and regular exercise may help minimize weight gain while on this medication.
- If weight gain becomes problematic, a healthcare provider might consider adjusting the dose or switching to an alternative medication, though patients should never stop taking Lyrica suddenly without medical supervision.
It's essential to prioritize the patient's overall health and well-being, considering the potential benefits and risks of pregabalin treatment, including the risk of weight gain. Regular monitoring of weight and discussion of any significant changes with a healthcare provider are crucial for patients taking Lyrica.